{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T11:03:08Z","timestamp":1779015788604,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T00:00:00Z","timestamp":1602979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic hypersensitivity pneumonitis (CHP) remains a diagnostic challenge. The process of collecting and extracting serum and droppings from causative animals for the inhalation challenge test is complicated and the risk of inducing disease progression exists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the utility and safety of an inhalation challenge test using pigeon eggs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pigeon eggs were pasteurized and mixed with a saline solution to produce an inhalation fluid. An inhalation challenge test was conducted on 19 patients with bird\u2010related CHP and 17 patients with interstitial lung disease other than bird\u2010related CHP. To identify antigens in pigeon eggs, the antigen\u2010antibody responses of the pigeon eggs and serum from patients were evaluated using Western blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean changes in C\u2010reactive protein, alveolar\u2010arterial oxygen difference, erythrocyte sedimentation rate, and lactate dehydrogenase significantly increased by 0.32\u00a0mg\/dL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.014), 7.8\u00a0Torr (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.002), 1.4\u00a0mm\/h (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.012), and 5.4 U\/mL (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0019), respectively, in bird\u2010related CHP group compared to the control 24\u00a0hours after the inhalation challenge test. Furthermore, within 24\u00a0hours of the inhalation test, the mean forced vital capacity decreased by 2.3% in the bird\u2010related CHP group compared with a decline of 0.05% in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.035). Serum collected from seven bird\u2010related CHP patients who underwent the inhalation challenge test and reacted to antigens with molecular weights of 37\u201075 KDa, and these molecular weights were consistent with egg albumin and globulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Since a mild response was observed after the inhalation challenge test using pigeon eggs, this test was an obvious candidate for diagnosing bird\u2010related CHP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13752","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T14:43:47Z","timestamp":1601736227000},"page":"1381-1390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhalation challenge test using pigeon eggs for chronic hypersensitivity pneumonitis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8691-7773","authenticated-orcid":false,"given":"Ryo","family":"Okuda","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"},{"name":"Department of Pathology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamiko","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Pathology Kanagawa Cardiovascular and Respiratory Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine the University of Tokyo  Tokyo 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