{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:19:17Z","timestamp":1791328757213,"version":"4.3.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["SDAP2019\/6359"],"award-info":[{"award-number":["SDAP2019\/6359"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Conduct a systematic review and meta\u2010analysis examining the association between hypertensive disorders of pregnancy (HDP) and risk of asthma, eczema, food allergies and allergic rhinitis in the offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A systematic review and random\u2010effects meta\u2010analyses were used to synthesize the published literature. PRISMA guidelines were followed throughout. Two independent reviewers carried out data extraction and quality assessment of included studies. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to assess certainty of findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Sources<\/jats:title><jats:p>A systematic search of PubMed, Embase, Web of Science and CINAHL was performed from inception of databases\u201021 April 2020, supplemented by hand\u2010searching reference lists of included articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Eligibility Criteria<\/jats:title><jats:p>Two reviewers independently reviewed titles, abstracts and full\u2010text articles. English language, cohort, case\u2010control and cross\u2010sectional published studies examining the association between HDP (primary exposure: pre\u2010eclampsia; secondary exposures: all other HDP) and asthma, eczema, food allergies and allergic rhinitis were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 2833 studies retrieved, 14 studies met inclusion criteria. Of these, 11 studies reported evidence of association between HDP and atopic disorders. Thirteen studies reported estimates for asthma. Seven of these included adjusted estimates (including 3\u00a0645\u00a0773 participants) for a pre\u2010eclampsia\u2010asthma relationship resulting in a pooled odds ratio (OR) of 1.14 (95% CI: 1.04, 1.26) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a062%). However, this OR was reduced to 1.08 (95% CI: (0.78, 1.48) when the large registry\u2010based cohort studies were excluded, and only studies using parent\u2010reported measures to determine a diagnosis of asthma were included. Four studies included adjusted estimates (including 254\u00a0998 participants) for other HDP and asthma (pooled OR: 1.02, 95% CI: 0.96, 1.09) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%). Two studies provided adjusted estimates (including 1\u00a0699\u00a0663 participants) for a pre\u2010eclampsia\u2010eczema relationship (pooled OR: 1.06, 95% CI: 0.98, 1.14) (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00%). One study including pre\u2010eclampsia\u2010food allergies was identified (OR: 1.28, 95% CI: 1.11, 1.46). Three studies examined a HDP (including pre\u2010eclampsia) and allergic rhinitis relationship, with effect estimates ranging from 1.14 to 2.10. Studies were classified as low or low\u2010moderate risk of bias, while GRADE certainty of findings were low to very low.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While pre\u2010eclampsia was associated with a possible increased risk of asthma in offspring, there was no evidence for a relationship between other HDP and asthma. There is a lack of published literature examining the association between HDP and eczema, food allergy and allergic rhinitis. Further primary research is warranted to gain a better understanding of the association between HDP and the risk of childhood atopic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p>Review protocol in appendix.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13754","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T03:22:44Z","timestamp":1602300164000},"page":"29-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association between hypertensive disorders of pregnancy and the risk of asthma, eczema and allergies in offspring: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"51","author":[{"given":"Nicola","family":"Conlan","sequence":"first","affiliation":[{"name":"School of Public Health, Western Gateway Building University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-0484","authenticated-orcid":false,"given":"Gillian M.","family":"Maher","sequence":"additional","affiliation":[{"name":"School of Public Health, Western Gateway Building University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukainah Y.","family":"Al Khalaf","sequence":"additional","affiliation":[{"name":"School of Public Health, Western Gateway Building University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus P.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"INFANT Research Centre University College Cork  Cork Ireland"},{"name":"Department of Obstetrics and Gynaecology University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali S.","family":"Khashan","sequence":"additional","affiliation":[{"name":"School of Public Health, Western Gateway Building University College Cork  Cork Ireland"},{"name":"INFANT Research Centre University College Cork  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12633"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2016.126"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2018.05.004"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.102"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.09.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00673-2016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06707.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.10.037"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0806OC"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24659"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01206.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00378-2018"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.05.035"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d549"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12344"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.060"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2017.0786"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-14-101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201804-0770OC"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025395405101"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00643-2015"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202-158OC"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12160"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2012.03997.x"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-6-21"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181fdcabe"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a819a1"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.14.0170"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2068"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.13754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cea.13754","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.13754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T14:56:50Z","timestamp":1693580210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.13754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/cea.13754"],"URL":"https:\/\/doi.org\/10.1111\/cea.13754","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]},"assertion":[{"value":"2020-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}