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The impact of allergic multimorbidity was assessed in terms of allergic sensitization, allergic and respiratory symptoms, quality of life, type\u20102 inflammatory markers (exhaled nitric oxide, eosinophil activation markers, periostin), lung function, use of medication and background factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Subjects with asthma, rhinitis and eczema were more likely to be sensitized to seasonal allergens (67% vs 32%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), food allergens (54% vs 18%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and to have a higher degree of sensitization than subjects with only asthma (23% vs 10%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Subjects with allergic multimorbidity more often had allergic reactions to food (28% vs 10%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002), more respiratory symptoms and anxiety\/depression (40% vs, 14%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) than subjects with only asthma, despite having similar levels of type 2 inflammatory markers. Individuals with allergic multimorbidity were more likely to be diagnosed with asthma before the age of 12 (48% vs 27%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.016) and to have maternal heredity for allergy (53% vs 33%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011) than subjects with only asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and clinical relevance<\/jats:title><jats:p>Asthmatics with allergic multimorbidity are more likely to be sensitized to seasonal aeroallergens, food allergens and they have a higher degree of sensitization compared with those with only asthma. Allergic multimorbidity is associated with respiratory and allergy symptoms, anxiety and\/or depression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13759","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T19:29:16Z","timestamp":1602703756000},"page":"262-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Multimorbidity in asthma, association with allergy, inflammatory markers and symptom burden, results from the Swedish GA<sup>2<\/sup>LEN study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9172-9555","authenticated-orcid":false,"given":"Viiu","family":"Bl\u00f6ndal","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Respiratory, Allergy and Sleep Research Unit Uppsala University Uppsala 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