{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T22:32:07Z","timestamp":1779143527084,"version":"3.51.4"},"reference-count":76,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011747","name":"Novo Nordisk Foundation Center for Basic Metabolic Research","doi-asserted-by":"publisher","award":["NNF17OC0026698"],"award-info":[{"award-number":["NNF17OC0026698"]}],"id":[{"id":"10.13039\/501100011747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Asthma is an airway inflammatory disease and a major health problem worldwide. Anti\u2010inflammatory steroids and bronchodilators are the gold\u2010standard therapy for asthma. However, they do not prevent the development of the disease, and critically, a subset of asthmatics are resistant to steroid therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To elucidate the therapeutic potential of human \u03b2\u2010defensins (hBD), such as hBD2 mild to moderate and severe asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the role of hBD2 in a steroid\u2010sensitive, house dust mite\u2010induced allergic airways disease (AAD) model and a steroid\u2010insensitive model combining ovalbumin\u2010induced AAD with <jats:italic>C\u00a0muridarum<\/jats:italic> (Cmu) respiratory infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In both models, we demonstrated that therapeutic intranasal application of hBD2 significantly reduced the influx of inflammatory cells into the bronchoalveolar lavage fluid. Furthermore, key type 2 asthma\u2010related cytokines IL\u20109 and IL\u201013, as well as additional immunomodulating cytokines, were significantly decreased after administration of hBD2 in the steroid\u2010sensitive model. The suppression of inflammation was associated with improvements in airway physiology and treatment also suppressed airway hyper\u2010responsiveness (AHR) in terms of airway resistance and compliance to methacholine challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical relevance<\/jats:title><jats:p>These data indicate that hBD2 reduces the hallmark features and has potential as a new therapeutic agent in allergic and especially steroid\u2010resistant asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13766","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T02:16:54Z","timestamp":1603505814000},"page":"120-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Human \u03b2\u2010defensin\u20102 suppresses key features of asthma in murine models of allergic airways disease"],"prefix":"10.1111","volume":"51","author":[{"given":"James W.","family":"Pinkerton","sequence":"first","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle, &amp; Hunter Medical Research Institute Newcastle NSW Australia"},{"name":"National Heart &amp; Lung Institute Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle, &amp; Hunter Medical Research Institute Newcastle NSW Australia"},{"name":"Centre for Inflammation Faculty of Science School of Life Sciences Centenary Institute and University of Technology Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Koeninger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole S.","family":"Armbruster","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole G.","family":"Hansbro","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle, &amp; Hunter Medical Research Institute Newcastle NSW Australia"},{"name":"Centre for Inflammation Faculty of Science School of Life Sciences Centenary Institute and University of Technology Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra C.","family":"Brown","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle, &amp; Hunter Medical Research Institute Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjith","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Faculty of Science School of Life Sciences Centenary Institute and University of Technology Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijie","family":"Shen","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Faculty of Science School of Life Sciences Centenary Institute and University of Technology Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nisar","family":"Malek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience University of Queensland Brisbane Qld Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Nordkild","sequence":"additional","affiliation":[{"name":"Department of Biology University of Copenhagen Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay C.","family":"Horvat","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs University of Newcastle, &amp; Hunter Medical Research Institute Newcastle NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6991-0828","authenticated-orcid":false,"given":"Benjamin A. 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