{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T03:55:56Z","timestamp":1777262156298,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T00:00:00Z","timestamp":1613865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic reactions to food allergens usually occur after ingestion. However, fear of reactions to airborne peanut is a common concern for people with peanut allergy. There are no scientific reports on severe reactions with airborne peanut allergen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the occurrence of allergic reactions in peanut\u2010allergic children undergoing airborne peanut challenge and to determine levels of airborne peanut protein in a separate experimental evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010four children with peanut allergy underwent an airborne peanut challenge, 0.5\u00a0m from a bowl of peanuts for 30\u00a0min under controlled conditions. In a separate experiment, airborne peanut proteins from roasted and dry\u2010roasted peanuts were collected at varying distances and at varying times with an electret SensAbues filter connected to an air pump. Collected airborne peanut proteins were extracted, dissolved and detected by ELISA. Basophil activation test was used to confirm biological activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No moderate\/severe allergic reactions to airborne peanut allergens were observed. Two children (2%) had mild rhino\u2010conjunctivitis which required no treatment. The IgE\u2010antibodies to peanut or Ara h 2 did not predict a reaction. In the experimental set\u2010up, biological active peanut proteins were detected, in a very low amount, in median 166\u00a0ng\/ml for dry\u2010roasted and 33\u00a0ng\/ml for roasted peanuts and decreased dramatically when the collection occurred at a greater distance (0.5\u20132\u00a0m) from the peanut source. Increased exposure time did affect the amount of collected peanut protein at 0\u00a0m, and the highest median was obtained after 60\u00a0min (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.012); for time trend <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0006.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>Allergic reactions to airborne peanut proteins are rare and cannot be predicted by high levels of IgE\u2010antibodies to peanut or Ara h 2. Only small amounts of biologically active peanut proteins were detected in the air and seem unlikely to trigger moderate\/severe allergic reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13848","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T16:30:27Z","timestamp":1612629027000},"page":"585-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Peanuts in the air \u2010 clinical and experimental studies"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-4512","authenticated-orcid":false,"given":"Sofia","family":"Lov\u00e9n Bj\u00f6rkman","sequence":"first","affiliation":[{"name":"Sachs\u2019 Children and Youth Hospital S\u00f6dersjukhuset Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrika","family":"Sederholm","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6759-346X","authenticated-orcid":false,"given":"Natalia","family":"Ballardini","sequence":"additional","affiliation":[{"name":"Sachs\u2019 Children and Youth Hospital S\u00f6dersjukhuset Stockholm Sweden"},{"name":"Department of Clinical Science and Education S\u00f6dersjukhuset Karolinska Institutet Stockholm Sweden"},{"name":"Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olof","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Lundahl","sequence":"additional","affiliation":[{"name":"Sachs\u2019 Children and Youth Hospital S\u00f6dersjukhuset Stockholm 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