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MPAACH is a paediatric AD cohort, aged 1\u20132, recruited through hospital\/community settings between 2016 and 2018. We analysed these groupings' associations with AD biomarkers: skin<jats:italic>FLG<\/jats:italic>,<jats:italic>S100A8<\/jats:italic>and<jats:italic>S100A9<\/jats:italic>expression, total IgE, TEWL and AD severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An unbiased machine learning approach revealed five allergen clusters. The most common cluster (<jats:italic>N<\/jats:italic>\u00a0=\u00a0131), SPT<jats:sub>PEP,<\/jats:sub>had sensitization to peanut, egg and\/or pets. Three low prevalence clusters, which included children with allergen sensitization other than peanut, egg or pets, were combined into SPT<jats:sub>Other<\/jats:sub>. SPT<jats:sub>NEG<\/jats:sub>included children with no sensitization(s). SPT<jats:sub>PEP<\/jats:sub>children had higher median non\u2010lesional TEWL (16.9\u00a0g\/m<jats:sup>2<\/jats:sup>\/h) and IgE (90\u00a0kU\/L) compared with SPT<jats:sub>OTHER<\/jats:sub>(8.8\u00a0g\/m<jats:sup>2<\/jats:sup>\/h and 24\u00a0kU\/L;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01 and<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and SPT<jats:sub>NEG<\/jats:sub>(9\u00a0g\/m<jats:sup>2<\/jats:sup>\/h and 26\u00a0kU\/L;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003 and<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). SPT<jats:sub>PEP<\/jats:sub>children had lower median lesional (0.70) and non\u2010lesional (1.09)<jats:italic>FLG<\/jats:italic>expression compared with SPT<jats:sub>OTHER<\/jats:sub>(lesional: 0.9;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.047, non\u2010lesional: 1.78;<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01) and SPT<jats:sub>NEG<\/jats:sub>(lesional: 1.47;<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, non\u2010lesional: 2.21;<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). There were no differences among groupings in<jats:italic>S100A8<\/jats:italic>or<jats:italic>S100A9<\/jats:italic>expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical relevance<\/jats:title><jats:p>In this largely clinic\u2010based cohort of young children with AD, allergic sensitization to peanut, egg, cat or dog was associated with more severe disease and skin barrier function but not markers of cutaneous inflammation. These data need replicating in a population\u2010based cohort but may have important implications for understanding the interaction between AD and allergic sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13866","type":"journal-article","created":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T16:45:35Z","timestamp":1615826735000},"page":"666-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Sensitization to peanut, egg or pets is associated with skin barrier dysfunction in children with atopic dermatitis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-729X","authenticated-orcid":false,"given":"Michael G.","family":"Sherenian","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH USA"},{"name":"Division of Asthma Research Cincinnati Children's Hospital Medical Center Cincinnati OH 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