{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:46:01Z","timestamp":1788396361493,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergen immunotherapy (AIT) is the only disease\u2010modifying treatment in patients with seasonal allergic rhinoconjunctivitis (SAR). Its efficacy depends on the precise identification of the triggering allergen. However, diagnostics based on retrospective clinical history and sensitization to whole extracts (SWE) often leads to equivocal results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the usability and impact of a recently established algorithm for a clinical decision support system (@IT2020\u2010CDSS) for SAR and its diagnostic steps [anamnesis, SWE (skin prick test or serum IgE), component resolved diagnosis, CRD, and real\u2010time digital symptom recording, eDiary] on doctor's AIT prescription decisions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After educational training on the @IT2020\u2010CDSS algorithm, 46 doctors (18 allergy specialists, AS, and 28 general practitioners, GP) expressed their hypothetical AIT prescription for 10 clinical index cases. Decisions were recorded repeatedly based on different steps of the algorithm. The usability and perceived impact of the algorithm were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The combined use of CRD and an eDiary increased the hypothetical AIT prescriptions, both among AS and GP (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). AIT prescription for pollen and <jats:italic>Alternaria<\/jats:italic> allergy based on anamnesis and SWE was heterogeneous but converged towards a consensus by integrating CRD and eDiary information. Doctors considered the algorithm useful and recognized its potential in enhancing traditional diagnostics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and clinical implications<\/jats:title><jats:p>The implementation of CRD and eDiary in the @IT2020\u2010CDSS algorithm improved consensus on AIT prescription for SAR among AS and GP. The potential usefulness of a CDSS for aetiological diagnosis of SAR and AIT prescription in real\u2010world clinical practice deserves further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13867","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T03:50:56Z","timestamp":1616557856000},"page":"821-828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["@IT2020: An innovative algorithm for allergen immunotherapy prescription in seasonal allergic rhinitis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-0568","authenticated-orcid":false,"given":"Stefania","family":"Arasi","sequence":"first","affiliation":[{"name":"Allergy Unit \u2010 Area of Translational Research in Pediatric Specialities Bambino Ges\u00f9 Children's Hospital IRCCS Rome Italy"},{"name":"Department of Pediatric Pneumology, Immunology and Critical Care Medicine Charit\u00e9 Universit\u00e4tsmedizin \u2010 Berlin Berlin Germany"},{"name":"Department of Pediatrics Unit of Allergy University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sveva","family":"Castelli","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology, Immunology and Critical Care Medicine Charit\u00e9 Universit\u00e4tsmedizin \u2010 Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Di Fraia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology, Immunology and Critical Care Medicine Charit\u00e9 Universit\u00e4tsmedizin \u2010 Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Villalta","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit \u201cS. Maria degli Angeli\u201d Hospital Pordenone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Pediatric Allergology Unit Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Perna","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology, Immunology and Critical Care Medicine Charit\u00e9 Universit\u00e4tsmedizin \u2010 Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Dramburg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology, Immunology and Critical Care Medicine Charit\u00e9 Universit\u00e4tsmedizin \u2010 Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonia","family":"Brighetti","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariaelisabetta","family":"Conte","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit \u201cS. Maria degli Angeli\u201d Hospital Pordenone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Martelli","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Unit \u201cS. Maria degli Angeli\u201d Hospital Pordenone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifigenia","family":"Sfika","sequence":"additional","affiliation":[{"name":"Pediatric Allergology Unit Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Travaglini","sequence":"additional","affiliation":[{"name":"Department of Biology University of Rome \u201cTor Vergata\u201d Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Luigi","family":"Verardo","sequence":"additional","affiliation":[{"name":"Center of Aerobiology ARPA Pordenone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Villella","sequence":"additional","affiliation":[{"name":"Pediatric Allergology Unit Sandro Pertini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5485-0324","authenticated-orcid":false,"given":"Paolo Maria","family":"Matricardi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Pneumology, Immunology and Critical Care Medicine Charit\u00e9 Universit\u00e4tsmedizin \u2010 Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69283-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13317"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13201"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-015-0079-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2013.07.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.01.042"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01280.x"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"36","article-title":"Component\u2010resolved diagnosis to optimize allergen\u2010specific immunotherapy in the Mediterranean area","volume":"17","author":"Valenta R","year":"2007","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353113"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12563"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-7-15"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13953"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.01.053"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12562"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-020-00870-z"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2196\/16767"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.2196\/16642"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13230"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13165"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy8020085"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02116"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2015.07.019"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13264"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.09.033"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-4-16"}],"container-title":["Clinical &amp; 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