{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:49:36Z","timestamp":1790866176939,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Food hypersensitivity (FHS), including food allergy, coeliac disease and food intolerance, is a major public health issue. The Food Standards Agency (FSA), an independent UK Government department working to protect public health and consumers\u2019 wider interests in food, sought to identify research priorities in the area of FHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A priority setting exercise was undertaken, using a methodology adapted from the James Lind Alliance\u2014the first such exercise with respect to food hypersensitivity. A UK\u2010wide public consultation was held to identify unanswered research questions. After excluding diagnostics, desensitization treatment and other questions which were out of scope for FSA or where FSA was already commissioning research, 15 indicative questions were identified and prioritized by a range of stakeholders, representing food businesses, patient groups, health care and academia, local authorities and the FSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>295 responses were received during the public consultation, which were categorized into 70\u00a0sub\u2010questions and used to define 15\u00a0key evidence uncertainties (\u2018indicative questions\u2019) for prioritization. Using the JLA prioritization framework, this resulted in 10 priority uncertainties in evidence, from which 16 research questions were developed. These could be summarized under the following 5 themes: communication of allergens both within the food supply chain and then to the end consumer (ensuring trust in allergen communication); the impact of socio\u2010economic factors on consumers with FHS; drivers of severe reactions; mechanism(s) underlying loss of tolerance in FHS; and the risks posed by novel allergens\/processing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this first research prioritization exercise for food allergy and FHS, key priorities identified to protect the food\u2010allergic public were strategies to help allergic consumers to make confident food choices, prevention of FHS and increasing understanding of socio\u2010economic impacts. Diagnosis and treatment of FHS was not considered in this prioritization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.13983","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T19:01:26Z","timestamp":1625684486000},"page":"1322-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Identifying key priorities for research to protect the consumer with food hypersensitivity: A UK Food Standards Agency Priority Setting Exercise"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9862-5161","authenticated-orcid":false,"given":"Paul J.","family":"Turner","sequence":"first","affiliation":[{"name":"National Heart &amp; Lung Institute Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Andoh\u2010Kesson","sequence":"additional","affiliation":[{"name":"British Retail Consortium London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Baker","sequence":"additional","affiliation":[{"name":"Anaphylaxis Campaign Farnborough UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Baracaia","sequence":"additional","affiliation":[{"name":"Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha","family":"Barfield","sequence":"additional","affiliation":[{"name":"Food Standards Agency London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Barnett","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Bath Bath UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Brunas","sequence":"additional","affiliation":[{"name":"Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Han","family":"Chan","sequence":"additional","affiliation":[{"name":"Food Standards Agency London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Unilever Safety and Environmental Assurance Centre (SEAC Sharnbrook UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Cowan","sequence":"additional","affiliation":[{"name":"Katherine Cowan Consulting East Sussex UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Feeney","sequence":"additional","affiliation":[{"name":"King's College London Guy's and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Flanagan","sequence":"additional","affiliation":[{"name":"Reading Science Centre Mondel\u0113z International UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T.","family":"Fox","sequence":"additional","affiliation":[{"name":"King's College London Guy's and St Thomas\u2019 NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"George","sequence":"additional","affiliation":[{"name":"Allergy UK Sidcup UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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