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FeNO is elevated in asthma and allergic rhinitis, with IgE sensitization as a major determinant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to see whether there was an independent association between upper airway inflammatory disorders (UAID) and FeNO, after adjustment for asthma and sensitization, in a multi\u2010centre population\u2010based study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 741 subjects with current asthma and 4155 non\u2010asthmatic subjects participating in the second follow\u2010up of the European Community Respiratory Health Survey (ECRHS III) underwent FeNO measurements. Sensitization status was based on measurement of IgE against airborne allergens; information on asthma, UAID and medication was collected through interview\u2010led questionnaires. Independent associations between UAID and FeNO were assessed in adjusted multivariate regression models and test for interaction with perennial sensitization and asthma on the relation between UAID and FeNO were made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>UAID were associated with higher FeNO after adjusting for perennial sensitization, asthma and other confounders: with 4.4 (0.9\u20137.9) % higher FeNO in relation to current rhinitis and 4.8 (0.7\u20139.2) % higher FeNO in relation to rhinoconjunctivitis. A significant interaction with perennial sensitization was found in the relationship between current rhinitis and FeNO (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) and between rhinoconjunctivitis and FeNO (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03). After stratification by asthma and perennial sensitization, the association between current rhinitis and FeNO remained in non\u2010asthmatic subjects with perennial sensitization, with 12.1 (0.2\u201325.5) % higher FeNO in subjects with current rhinitis than in those without.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions &amp; Clinical Relevance<\/jats:title><jats:p>Current rhinitis and rhinoconjunctivitis was associated with higher FeNO, with an interaction with perennial sensitization. This further highlights the concept of united airway disease, with correlations between symptoms and inflammation in the upper and lower airways and that sensitization needs to be accounted for in the relation between FeNO and rhinitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14019","type":"journal-article","created":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T15:31:58Z","timestamp":1631979118000},"page":"297-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cross\u2010sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitization"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-8532","authenticated-orcid":false,"given":"Christina","family":"Krantz","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Accordini","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology and Medical Statistics Department of Diagnostics and Public Health University of Verona  Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Alving","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo G.","family":"Corsico","sequence":"additional","affiliation":[{"name":"Division of Respiratory Diseases IRCCS Policlinico San Matteo Foundation  Pavia Italy"},{"name":"Department of Internal Medicine and Therapeutics University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7827-7964","authenticated-orcid":false,"given":"Pascal","family":"Demoly","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pneumologie et Addictologie Centre Hospitalier Universitaire de Montpellier  Montpellier France"},{"name":"H\u00f4pital Arnaud de Villeneuve IDESP INSERM\u2010Univ Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogenes S.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University  Melbourne Vic. 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