{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:42:47Z","timestamp":1793148167339,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005362","name":"Universita degli Studi di Bari Aldo Moro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005362","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Benralizumab is effective in severe eosinophilic asthma (SEA), but suboptimal responses are observed in some patients. Although several factors have been associated with benralizumab response, no cluster analysis has yet been undertaken to identify different responsiveness sub\u2010phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify SEA sub\u2010phenotypes with differential responsiveness to benralizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and five patients diagnosed with SEA who had completed 6\u00a0months of benralizumab treatment were included in a hierarchical cluster analysis based on a set of clinical variables that can be easily collected in routine practice (age, age at disease onset, disease length, allergen sensitization status, blood eosinophil count, IgE levels, FEV<jats:sub>1<\/jats:sub>% predicted, nasal polyposis, bronchiectasis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four clusters were identified: Clusters 2 and 3 included patients with high levels of both IgE and eosinophils (type\u20102 biomarkers high), whereas Clusters 1 and 4 included patients with only one type\u20102 biomarker at a high level: IgE in Cluster 1 and eosinophils in Cluster 4. Clusters 2 and 3 (both type\u20102 biomarkers high) showed the highest response rate to benralizumab in terms of elimination of exacerbations (79% and 80% respectively) compared to Clusters 1 and 4 (52% and 60% respectively). When super\u2010response (the absence of exacerbation without oral corticosteroid use) was assessed, Cluster 2, including patients with more preserved lung function than the other clusters, but comparable exacerbation rate, oral corticosteroid use and symptom severity, was the most responsive cluster (87.5% of patients).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our cluster analysis identified benralizumab differential response sub\u2010phenotypes in SEA, with the potential of improving disease treatment and precision management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14026","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T00:46:21Z","timestamp":1633567581000},"page":"312-323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effectiveness of benralizumab in severe eosinophilic asthma: Distinct sub\u2010phenotypes of response identified by cluster analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-3806","authenticated-orcid":false,"given":"Danilo","family":"Di Bona","sequence":"first","affiliation":[{"name":"Department of Emergency and Organ Transplantation School and Chair of Allergology and Clinical Immunology University of Bari \u2010 Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Crimi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Maria","family":"D\u2019Uggento","sequence":"additional","affiliation":[{"name":"Department of Economics and Finance University of Bari \u2010 Aldo Moro  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alida","family":"Benfante","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Internal and Specialistic Medicine University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Filomena","family":"Caiaffa","sequence":"additional","affiliation":[{"name":"Allergology and Clinical Immunology Unit University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Calabrese","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences University of Campania \"Luigi Vanvitelli\"  Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Campisi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Elisiana","family":"Carpagnano","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences Neuroscience and Sense Organs Section of Respiratory Disease University \"Aldo Moro\" of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2367-3019","authenticated-orcid":false,"given":"Domenico","family":"Ciotta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry University of Salerno  Salerno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"D'Amato","sequence":"additional","affiliation":[{"name":"Division of Pneumology \"V. 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