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We then examined the association of PA with longitudinal trajectories of sensitization, wheeze and allergic comorbidities, which were previously derived using machine learning. Finally, we ascertained the relationship between PA and asthma severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PA was confirmed in 30\/959 participants with evaluable data. In the multivariate analysis, eczema in infancy (OR\u00a0=\u00a04.4, 95% CI 1.5\u201313.2, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), egg sensitization at age 3\u00a0years (OR\u00a0=\u00a09.7, 95% CI 3.3\u201329.9, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) and early\u2010life cat ownership (OR\u00a0=\u00a03.0, 95% CI 1.1\u20138.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04) were independent associates of PA. In the stratified analysis among 700 participants with genetic information, in children with early\u2010life eczema there was no difference in <jats:italic>FLG<\/jats:italic> mutations between children with and without PA (3\/18 [16.7%] vs. 42\/220 [19.1%], <jats:italic>p<\/jats:italic>\u00a0=\u00a01.00). In contrast, among children without eczema, those with PA were almost eight times more likely to have <jats:italic>FLG<\/jats:italic> mutations (2\/6 [33.3%] vs. 27\/456 [5.9%], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.049). We observed associations between PA and multiple allergic sensitization profiles derived using machine learning, with ~60\u2010fold increase in risk among individuals assigned to multiple early sensitization. PA was significantly associated with persistent wheeze (but not other wheeze phenotypes), and with trajectories of atopic disease characterized by co\u2010morbid persistent eczema and wheeze (but not with transient phenotypes). Children with PA were more likely to have asthma, but among asthmatics we found no evidence of an association between PA and asthma severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Peanut allergy is associated with multiple IgE sensitization and early\u2010onset persistent eczema and wheeze. <jats:italic>FLG<\/jats:italic> loss\u2010of\u2010function mutations were associated with peanut allergy in children without eczema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14103","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T18:20:03Z","timestamp":1643826003000},"page":"646-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Early\u2010life predictors and risk factors of peanut allergy, and its association with asthma in later\u2010life: Population\u2010based birth cohort study"],"prefix":"10.1111","volume":"52","author":[{"given":"Constantinos","family":"Kotsapas","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaos","family":"Nicolaou","sequence":"additional","affiliation":[{"name":"University of Nicosia Medical School  Nicosia Cyprus"},{"name":"Division of Infection, Immunity and Respiratory Medicine School of Biological Sciences Faculty of Biology, Medicine and Health University of Manchester, and Manchester Academic Health Science Centre and NIHR Biomedical Research Centre Manchester University Hospitals NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Haider","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute Imperial College London  London 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