{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:52:41Z","timestamp":1780584761986,"version":"3.54.1"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obesity is a common comorbid condition in adult asthmatics and known as a feature of asthma severity. However, the molecular mechanism under obesity\u2010induced inflammation has not yet been fully understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Considering the essential role of hydrophobic surfactant protein B (SP\u2010B) in lung function, SP\u2010B was targeted to examine its involvement in the development of obesity\u2010induced airway inflammation in asthmatics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The aim was to examine an alteration in circulating SP\u2010B according to obesity in adult asthmatics, 129 asthmatics were enrolled and classified into 3\u00a0groups (obese, overweight and normal\u2010weight groups) according to body mass index (BMI). Circulating SP\u2010B levels were determined by enzyme\u2010linked immunosorbent assay. Four single nucleotide polymorphisms of <jats:italic>SFTPB<\/jats:italic> gene were genotyped. Serum ceramide levels were measured by liquid chromatography\u2010tandem mass spectrometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly lower serum SP\u2010B levels were noted in the obese group than in the overweight or normal\u2010weight group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). The serum SP\u2010B level was significantly correlated with serum levels of C18:0 ceramide and transforming growth factor beta\u00a01 as well as BMI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.200; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.215; <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.332, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.050 for all). An inverse correlation was noted between serum SP\u2010B and fractional exhaled nitric oxide levels in female asthmatics (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.287, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009). Genetic predisposition of the <jats:italic>SFTPB<\/jats:italic> gene at 9306 A&gt;G to the obese and overweight groups was noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obesity altered ceramide metabolism leading to pulmonary surfactant dysfunction and impaired\u00a0resolution of airway inflammation, finally contributing to the phenotypes of obese asthmatics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14124","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T16:43:58Z","timestamp":1647449038000},"page":"1321-1329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Down\u2010regulated surfactant protein B in obese asthmatics"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4459-6486","authenticated-orcid":false,"given":"Thi Bich Tra","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Young","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Ju","family":"Yoo","sequence":"additional","affiliation":[{"name":"Asan Institute for Life Sciences Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-742X","authenticated-orcid":false,"given":"Ga\u2010Young","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Allergy, and Critical Care Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine Institute for Life Sciences  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-8964","authenticated-orcid":false,"given":"Seung\u2010Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Translational Research Laboratory for Inflammatory Disease Clinical Trial Center Ajou University Medical Center  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2614-0303","authenticated-orcid":false,"given":"Hae\u2010Sim","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Ajou University School of Medicine  Suwon 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