{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:15:53Z","timestamp":1785575753212,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI095219"],"award-info":[{"award-number":["U19AI095219"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23AI139352"],"award-info":[{"award-number":["K23AI139352"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL128241"],"award-info":[{"award-number":["R01HL128241"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AI007306"],"award-info":[{"award-number":["T32AI007306"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010135","name":"Finnish Medical Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of anosmia on quality\u2010of\u2010life (QoL) for patients with aspirin\u2010exacerbated respiratory disease (AERD) is poorly understood. We aimed to investigate how the severity of smell loss and olfactory dysfunction (OD) in patients with AERD affects their QoL, mental health and physical well\u2010being.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five validated QoL questionnaires (Sinonasal Outcome Test\u201022, Asthma Control Test, Healthy Days Core Module\u20104, Short Form\u201036 and Patient Health Questionnaire\u20104) and two newly developed questionnaires assessing severity and consequences of OD were electronically sent to all 2913 patients in the Brigham and Women's Hospital AERD registry. Responses were received from 853 participants for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 85% of participants reported a present diminished sense of smell and\/or taste, and 30% categorized their OD severity was, \u201cas bad as it can be.\u201d There were significant relationships between the severity of self\u2010reported OD and both psychological distress and general health scores, even after adjusting for asthma control. Additionally, incidence rates for physically and mentally unhealthy days in the prior month were higher for patients with moderate or severe OD than for normosmic patients. Patients with diminished smell responded that they could not identify spoiled food (86%), did not enjoy food (71%), felt unsafe (63%) and had encountered dangerous situations (51%) as consequences of their OD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anosmia and hyposmia severely impact the physical, emotional and mental health of AERD patients, and lead to safety concerns in their daily lives. The importance of olfaction and the relevance of OD to patients\u2019 QoL should be acknowledged and evaluated by clinicians caring for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14157","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T06:44:59Z","timestamp":1651646699000},"page":"1414-1421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Loss of smell in patients with aspirin\u2010exacerbated respiratory disease impacts mental health and quality of life"],"prefix":"10.1111","volume":"52","author":[{"given":"Raffi","family":"Tchekmedyian","sequence":"first","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Division of Allergy and Clinical Immunology Brigham and Women\u2019s Hospital  Boston Massachusetts USA"},{"name":"Department of Otorhinolaryngology \u2013 Head and Neck Surgery University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Buchheit","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Division of Allergy and Clinical Immunology Brigham and Women\u2019s Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Maurer","sequence":"additional","affiliation":[{"name":"Center for Clinical Investigation Brigham and Women's Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Gakpo","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine  Cleveland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotsna","family":"Mullur","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology Brigham and Women\u2019s Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian C.","family":"Bensko","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology Brigham and Women\u2019s Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M.","family":"Laidlaw","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Division of Allergy and Clinical Immunology Brigham and Women\u2019s Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2011.3.1.3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.03.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200404000-00026"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0807-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22249"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.27112"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2010.539625"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820926473"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2808"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2021.3379"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006919"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.6.635"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017502"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21387"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2009.01995.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.09.008"},{"issue":"4","key":"e_1_2_8_19_1","first-page":"1","article-title":"Health\u2010related quality of life surveillance\u2013United States, 1993\u20132002","volume":"54","author":"Zahran HS","year":"2005","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.50.6.613"},{"key":"e_1_2_8_21_1","unstructured":"National Center for Chronic Disease Prevention and Health Promotion DoPH.Health\u2010Related Quality of Life (HRQOL).2018.https:\/\/www.cdc.gov\/hrqol\/methods.htm"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-06575-7"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1054-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjw061"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb20975.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20101"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/bjt072"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/19458924211053118"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.3.317"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.5.497"},{"issue":"4","key":"e_1_2_8_31_1","first-page":"189","article-title":"Consequences of olfactory loss and adopted coping strategies","volume":"42","author":"Blomqvist EH","year":"2004","journal-title":"Rhinology"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.14157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cea.14157","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.14157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T16:56:36Z","timestamp":1692291396000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.14157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,17]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/cea.14157"],"URL":"https:\/\/doi.org\/10.1111\/cea.14157","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,17]]},"assertion":[{"value":"2022-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}