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The weight change in infancy was grouped into slow, on\u2010track and rapid. BMI status in childhood was stratified into low, normal and high groups and used as a time\u2010varying variable. The outcome was asthma, defined as two or more diagnoses of asthma separated by at least 1\u00a0year after 2\u2009years of age. The risk of asthma was assessed using Cox proportional hazard regression, with adjustment for sex, residence area at birth, economic status and feeding types in infancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 917,707 children born in Korea in 2008 and 2009, 271,871 were eligible for analysis. The risk of asthma was greater in groups with low birth weight (aHR 1.06, 95% CI 1.04 to 1.08), rapid body weight change during early infancy (aHR 1.08, 95% CI 1.07 to 1.10) and high BMI during childhood (aHR 1.06, 95% CI 1.04\u20131.08). The interaction of weight change during early infancy with BMI during childhood was significant for asthma (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). Rapid weight gain in infancy was associated with lower risk of asthma in those with low BMI during childhood; had no association with asthma in those with normal BMI during childhood; and was associated increased asthma risk in those with high BMI during childhood\u2014aHR 1.26 (95% CI 1.19 to 1.33) and aHR 1.33 (95% CI 1.12 to 1.56) compared with on\u2010track and slow infant weight gain, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low birth weight, high BMI during childhood and, in those with high childhood BMI, rapid weight gain during early infancy are associated with increased risk of childhood asthma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14221","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T08:21:08Z","timestamp":1661761268000},"page":"39-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Growth pattern during early infancy, body mass index during childhood and childhood asthma"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-0753","authenticated-orcid":false,"given":"Ju Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kangdong Sacred Heart Hospital Hallym University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-5729","authenticated-orcid":false,"given":"Eun Kyo","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kangnam Sacred Heart Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5632-5208","authenticated-orcid":false,"given":"Seung Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine Sunkyunkwan University School of Medicine  Suwon South 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