{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T14:14:12Z","timestamp":1772460852266,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004329","name":"Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic rhinosinusitis with nasal polyposis (CRSwNP) affects a significant number of asthmatic patients and is notably associated with a more difficult\u2010to\u2010control asthma and marked inflammation. We need more studies on this specific asthma phenotype and its possible subphenotypes, in order to better individualize treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to identify and characterize subphenotypes of asthma patients with CRSwNP using clinical, physiological and inflammatory variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>K\u2010means cluster analysis was performed on 17 clinical, physiological, and inflammatory variables from 1263 patients of all asthma severity and on a subpopulation of patients with asthma and CRSwNP. Study was registered on <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> (NCT 03694847).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On the overall population, three groups were identified. Cluster T1 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0708) are young, have a short asthma duration and a low prevalence of CRSwNP. Cluster T2 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0263) have the longest asthma duration and Cluster T3 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0292) are older with the shortest asthma duration. Patients in Clusters T2 and T3 have similar prevalences of CRSwNP. On the subpopulation of asthma with CRSwNP, three clusters were also identified. Cluster S1 (<jats:italic>n<\/jats:italic>\u00a0=\u00a083) have mild\u2010to\u2010moderate asthma with normal lung function. Clusters S2 (<jats:italic>N<\/jats:italic>\u00a0=\u00a053) and S3 (<jats:italic>N<\/jats:italic>\u00a0=\u00a042) include patients with severe asthma and decreased lung function, but those in Cluster S2 have a longer asthma duration, whereas those Cluster S3 have late\u2010onset asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite coexistence of asthma and CRSwNP, not all patients have the same evolution of their asthma. Different phenotypes of asthma with CRSwNP can be identified and exploration of the characteristics of these subgroups could lead to a better individualized, targeted management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14247","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T07:48:11Z","timestamp":1667288891000},"page":"52-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Heterogeneity of asthma with nasal polyposis phenotypes: A\u00a0cluster analysis"],"prefix":"10.1111","volume":"53","author":[{"given":"Isabelle","family":"Birs","sequence":"first","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec\u2010Universit\u00e9 Laval  Quebec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Eve","family":"Boulay","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec\u2010Universit\u00e9 Laval  Quebec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myl\u00e8ne","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec\u2010Universit\u00e9 Laval  Quebec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9anne","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec\u2010Universit\u00e9 Laval  Quebec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3485-9393","authenticated-orcid":false,"given":"Louis\u2010Philippe","family":"Boulet","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec\u2010Universit\u00e9 Laval  Quebec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.11.34"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.008"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00037905"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13026"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00964.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-014-0440-x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.4193\/Rhino09.095"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1754OC"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200906-0896OC"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0482-9"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.09.020"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.12.018"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.24154"},{"key":"e_1_2_12_15_1","unstructured":"National Heart Lung and Blood Institute World Health Organization.Global strategy for asthma management and prevention 2017.www.ginasthma.org. 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