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Specific IgE assays were performed at 10\u2009years of age. Questions regarding a cough without a cold were used to build a latent class model of cough over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 961 children included in the study, apart from the never\/infrequent trajectory (59.9%), eight trajectories of cough without a cold were identified: five grouped acute transient classes (24.1%), moderate transient (6.8%), late persistent (4.8%) and early persistent (4.4%). Compared with the never\/infrequent trajectory, the other trajectories were significantly associated with wheezing, asthma and allergic rhinitis. For asthma, the strongest association was with the early persistent trajectory (OR<jats:sub>a<\/jats:sub>\u00a0=\u00a031.00 [14.03\u201368.51]), which was inversely associated with farm environment (OR<jats:sub>a<\/jats:sub>\u00a0=\u00a00.39 [0.19\u20130.77]) and had a high prevalence of cough triggers and unremitting wheeze. Late and early persistent trajectories were also associated with food allergy. Atopic sensitization was only associated with the late persistent trajectory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Late and early persistent coughs without a cold are positively associated with atopic respiratory diseases and food allergy. Children having recurrent cough without a cold with night cough and triggers would benefit from an asthma and allergy assessment. Growing up on a farm is associated with reduced early persistent cough.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14257","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T12:58:01Z","timestamp":1669899481000},"page":"429-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Trajectories of cough without a cold in early childhood and associations with atopic diseases"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-9864","authenticated-orcid":false,"given":"Amandine","family":"Divaret\u2010Chauveau","sequence":"first","affiliation":[{"name":"Paediatric Allergy Department University Hospital of Nancy  Vandoeuvre\u2010les\u2010Nancy France"},{"name":"EA3450 D\u00e9veloppement Adaptation et Handicap (DevAH) University of Lorraine  Nancy France"},{"name":"UMR 6249 Chrono\u2010environment, CNRS and University of Franche\u2010Comt\u00e9  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