{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:38:16Z","timestamp":1787319496222,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2023,3]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n The aim of this study was to systematically review the evidence across studies that assessed DNA methylome variations in association with food allergy (FA).<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n A systematic review of the literature and meta\u2010analysis were carried out within several databases. However, the risk of bias in the included articles was not evaluated.<\/jats:p>\n <\/jats:sec>\n \n Data sources<\/jats:title>\n PubMed, Cochrane Database of Systematic Reviews,\u00a0and Web of Science were used to search up to July 2022.<\/jats:p>\n <\/jats:sec>\n \n Eligibility criteria<\/jats:title>\n We included targeted and epigenome\u2010wide association studies (EWASs) that assessed DNA methylome alterations in association with FA in adult or paediatric populations.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 366 publications, only 16 were retained, which were mainly focused on FA in children. Seven candidate gene\u2010targeted studies found associations in Th1\/Th2 imbalance (\n IL4<\/jats:italic>\n ,\n IL5<\/jats:italic>\n ,\n IL10<\/jats:italic>\n ,\n INFG<\/jats:italic>\n ,\n IL2 and IL12B<\/jats:italic>\n genes), regulatory T cell function (\n FOXP3<\/jats:italic>\n gene), Toll\u2010like receptors pathway (\n TLR2<\/jats:italic>\n ,\n CD14<\/jats:italic>\n genes) and digestive barrier integrity (\n FLG<\/jats:italic>\n gene). Nine EWAS assessed the association with peanut allergy (n\u00a0=\u00a03), cow's milk allergy (\n n<\/jats:italic>\n \u00a0=\u00a02) or various food allergens (\n n<\/jats:italic>\n \u00a0=\u00a04). They highlighted 11 differentially methylated loci in at least two studies (\n RPS6KA2<\/jats:italic>\n ,\n CAMTA1<\/jats:italic>\n ,\n CTBP2<\/jats:italic>\n ,\n RYR2<\/jats:italic>\n ,\n TRAPPC9<\/jats:italic>\n ,\n DOCK1<\/jats:italic>\n ,\n GALNTL4<\/jats:italic>\n ,\n HDAC4<\/jats:italic>\n ,\n UMODL1<\/jats:italic>\n ,\n ZAK and TNS3<\/jats:italic>\n genes). Among them,\n CAMTA1<\/jats:italic>\n and\n RPS6KA2<\/jats:italic>\n , and\n CTBP2<\/jats:italic>\n are involved in regulatory T cell function and Th2 cell differentiation, respectively. Gene\u2010functional analysis revealed two enriched gene clusters involved in immune responses and protein phosphorylation. ChIP\u2010X Enrichment Analysis 3 showed eight significant transcription factors (\n RXRA<\/jats:italic>\n ,\n ZBTB7A<\/jats:italic>\n ,\n ESR1<\/jats:italic>\n ,\n TCF3<\/jats:italic>\n ,\n MYOD1<\/jats:italic>\n ,\n CTCF<\/jats:italic>\n ,\n GATA3 and CBX2<\/jats:italic>\n ). Ingenuity Pathway Analysis identified canonical pathways involved, among other, in B cell development, pathogen\u2010induced cytokine storm signalling pathway and dendritic cell maturation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This review highlights the involvement of epigenomic alterations of loci in Th1\/Th2 and regulatory T cell differentiation in both candidate gene studies and EWAS. These alterations provide a better insight into the mechanistic aspects in FA pathogenesis and may guide the development of epigenome\u2010based biomarkers for FA.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cea.14277","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T03:50:37Z","timestamp":1675914637000},"page":"259-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Epigenome alterations in food allergy: A systematic review of candidate gene and\n epigenome\u2010wide<\/scp>\n association studies"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-1675","authenticated-orcid":false,"given":"Ramia","family":"Safar","sequence":"first","affiliation":[{"name":"INSERM, UMR_S1256, NGERE \u2013 Nutrition, Genetics, and Environmental Risk Exposure, Faculty of Medicine of Nancy University of Lorraine Vandoeuvre\u2010l\u00e8s\u2010Nancy 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Investigaci\u00f3n Biomedica de Malaga\u2010IBIMA and ARADyAL Malaga Spain"},{"name":"Laboratory for Nanostructures for the Diagnosis and Treatment of Allergic Diseases Andalusian Center for Nanomedicine and Biotechnology (BIONAND) Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Vieths","sequence":"additional","affiliation":[{"name":"Paul\u2010Ehrlich\u2010Institut Federal Institute for Vaccines and Biomedicines Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5488-5700","authenticated-orcid":false,"given":"Domingo","family":"Barber","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas, Facultad de Medicina, IMMA Universidad San Pablo CEU, CEU Universities Madrid Spain"},{"name":"ARADyAL\u2010RD16\/0006\/0015 Thematic Network and Cooperative Research Centers, ISCIII Madrid 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