{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:00:53Z","timestamp":1787065253476,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HR16C0001"],"award-info":[{"award-number":["HR16C0001"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aspirin\u2010exacerbated respiratory disease (AERD) is a phenotype of severe asthma, but its disease course has not been well documented compared with that of aspirin\u2010tolerant asthma (ATA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the long\u2010term clinical outcomes between AERD and ATA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>AERD patients were identified by the diagnostic code and positive bronchoprovocation test in a real\u2010world database. Longitudinal changes in lung function, blood eosinophil\/neutrophil counts, and annual numbers of severe asthma exacerbations (AEx) were compared between the AERD and the ATA groups. Within a year after baseline, two or more severe AEx events indicated severe AERD, whereas less than two AEx events indicated nonsevere AERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among asthmatics, 353 had AERD in which 166 and 187 patients had severe and nonsevere AERD, respectively, and 717 had ATA. AERD patients had significantly lower FEV1%, higher blood neutrophil counts, and higher sputum eosinophils (%) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) as well as higher levels of urinary LTE4 and serum periostin, and lower levels of serum myeloperoxidase and surfactant protein D (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01) than those with ATA. In a 10\u2010year follow\u2010up, the severe AERD group maintained lower FEV1% with more severe AEs than the nonsevere AERD group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Relevance<\/jats:title>\n                    <jats:p>We demonstrated that AERD patients presented poorer long\u2010term clinical outcomes than ATA patients in real\u2010world data analyses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.14362","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T01:42:18Z","timestamp":1687138938000},"page":"941-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010term clinical outcomes of aspirin\u2010exacerbated respiratory disease: Real\u2010world data from an adult asthma cohort"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8918-9353","authenticated-orcid":false,"given":"Youngsoo","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Allergy &amp; 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