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Dysregulated expression of various types of SOCS molecules was indicated in multiple types of allergic diseases. SOCS1, SOCS2, SOCS3, SOCS5, and cytokine\u2010inducible SH2 domain protein (CISH) can differentially exert anti\u2010allergic impacts through different mechanisms, such as suppressing Th2 cell development and activation, reducing eosinophilia, decreasing IgE production, repressing production of pro\u2010allergic chemokines, promoting Treg cell differentiation and activation, suppressing Th17 cell differentiation and activation, increasing anti\u2010allergic Th1 responses, inhibiting M2 macrophage polarization, modulating survival and development of mast cells, reducing pro\u2010allergic activity of keratinocytes, and suppressing pulmonary fibrosis. Although some anti\u2010allergic effects were attributed to SOCS3, it can perform pro\u2010allergic impacts through several pathways, such as promoting Th2 cell development and activation, supporting eosinophilia, boosting pro\u2010allergic activity of eosinophils, increasing IgE production, enhancing the expression of the pro\u2010allergic chemokine receptor, reducing Treg cell differentiation, increasing pro\u2010allergic Th9 responses, as well as supporting mucus secretion and collagen deposition. In this review, we discuss the contrasting roles of SOCS proteins in contexts of allergic disorders to provide new insights regarding the pathophysiology of these diseases and possibly explore SOCS proteins as potential therapeutic targets for alleviating allergies.<\/jats:p>","DOI":"10.1111\/cea.14385","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T05:42:51Z","timestamp":1693287771000},"page":"1147-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Aberrant expression of suppressor of cytokine signaling (<scp>SOCS<\/scp>) molecules contributes to the development of allergic diseases"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8180-0602","authenticated-orcid":false,"given":"Abdollah","family":"Jafarzadeh","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Medicine Kerman University of Medical Sciences  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