{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:27:08Z","timestamp":1790659628918,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fungal sensitization (FS) exacerbates asthma in patients who have elevated type 2 inflammatory response. Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin (IL)\u20104 and IL\u201013, key and central drivers of type 2 inflammation in multiple diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This post hoc analysis, funded by the manufacturers of dupilumab, was conducted to assess dupilumab efficacy in patients from the phase 3 LIBERTY ASTHMA QUEST trial (NCT02414854) and TRAVERSE open\u2010label extension (NCT02134028) study who had uncontrolled, moderate\u2010to\u2010severe asthma with type 2 inflammatory phenotype (defined as blood eosinophil count \u2265150 cells\/\u03bcL or FeNO \u226525\u2009ppb) and with FS (defined as IgE specific to <jats:italic>Alternaria alternata<\/jats:italic>, <jats:italic>Aspergillus fumigatus<\/jats:italic> or <jats:italic>Cladosporium herbarum<\/jats:italic>\u2009&gt;0.35\u2009IU\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated annualized rate of severe exacerbations (AER), change from baseline in pre\u2010bronchodilator (BD) forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>), asthma control (per 5\u2010item Asthma Control Questionnaire [ACQ\u20105]) and biomarker levels (blood eosinophil count, fractional exhaled nitric oxide [FeNO], total IgE, fungal\u2010specific IgEs, thymus and activation\u2010regulated chemokine [TARC] and eotaxin\u20103).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dupilumab vs. placebo reduced AER, improved pre\u2010BD FEV<jats:sub>1<\/jats:sub> and asthma control (ACQ\u20105), and reduced serum IgE levels, blood eosinophil count, TARC, eotaxin\u20103 and FeNO in patients both with and without FS after 52\u2009weeks of treatment in QUEST. Reductions in asthma exacerbation rates and improvements in all other variables were sustained over the TRAVERSE open\u2010label extension study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dupilumab demonstrated efficacy during prolonged treatment in patients with uncontrolled, moderate\u2010to\u2010severe asthma with FS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14389","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T03:40:51Z","timestamp":1695786051000},"page":"1020-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy of dupilumab in patients with uncontrolled, moderate\u2010to\u2010severe asthma with fungal sensitization"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5951-3239","authenticated-orcid":false,"given":"Jonathan","family":"Corren","sequence":"first","affiliation":[{"name":"David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola A.","family":"Hanania","sequence":"additional","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Busse","sequence":"additional","affiliation":[{"name":"UW Allergy, Pulmonary and Critical Care Medicine University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence D.","family":"Sher","sequence":"additional","affiliation":[{"name":"Peninsula Research Associates  Rolling Hills Estates California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Altincatal","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Hardin","sequence":"additional","affiliation":[{"name":"Sanofi  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda P.","family":"Mannent","sequence":"additional","affiliation":[{"name":"Sanofi  Chilly\u2010Mazarin France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Amin","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Lederer","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Soler","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juby A.","family":"Jacob\u2010Nara","sequence":"additional","affiliation":[{"name":"Sanofi  Bridgewater New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Rowe","sequence":"additional","affiliation":[{"name":"Sanofi  Bridgewater New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamo","family":"Deniz","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals Inc.  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