{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:23:34Z","timestamp":1707956614209},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Local application site reactions are common with sublingual allergy immunotherapy (AIT)\u2010tablets for the treatment of allergic rhinitis\/conjunctivitis (AR\/C) and occasionally lead to treatment discontinuation. Because of the lower mast cell density in the vestibular mucosa than the sublingual area, vestibular AIT\u2010tablet administration may result in fewer adverse events (AEs). This pilot study evaluated the tolerability of the vestibular administration route of AIT\u2010tablets compared with the sublingual route in adult subjects with AR\/C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adults (<jats:italic>n<\/jats:italic>\u2009=\u2009164) aged 18\u201365\u2009years with AR\/C treated with daily birch pollen, grass pollen, ragweed pollen or house dust mite AIT in tablet form were randomized 1:1 to vestibular or sublingual administration for 28\u2009days, followed by 28\u2009days of sublingual administration only. The primary endpoint was the severity (mild, moderate, severe) of local treatment\u2010related adverse events (TRAEs) during the first 28\u2009days of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the first 28\u2009days, the percentage of subjects in the vestibular and sublingual groups reporting mild TRAEs were 55.6% versus 50.6%, respectively; moderate TRAEs were 27.2% versus 30.1%; and severe TRAEs were 12.3% versus 6.0% (<jats:italic>p<\/jats:italic>\u2009=\u2009.16). In the vestibular group, 95.1% of the subjects experienced at least one TRAE during the first period versus 81.9% in the sublingual group (<jats:italic>p<\/jats:italic>\u2009=\u2009.01) and discontinuation rates due to AEs were higher (12.3% vs. 3.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The frequencies of subjects experiencing severe TRAEs, at least one TRAE, and discontinuations due to AEs at the initiation of AIT\u2010tablets were numerically higher with vestibular administration than sublingual administration. Sublingual administration should remain the standard of care for subjects treated with AIT\u2010tablets for AR\/C.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cea.14427","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T11:40:36Z","timestamp":1700653236000},"page":"120-129","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tolerability of sublingual versus vestibular allergy immunotherapy tablet administration: A randomized pilot study"],"prefix":"10.1111","volume":"54","author":[{"given":"Marie\u2010Lee","family":"Simard","sequence":"first","affiliation":[{"name":"Clinique Sp\u00e9cialis\u00e9e en Allergie de la Capitale  Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalija","family":"Novak","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Dermatology and Allergology University Hospital Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Philippe","family":"Drolet","sequence":"additional","affiliation":[{"name":"Clinique Sp\u00e9cialis\u00e9e en Allergie de la Capitale  Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Claude","family":"Joly","sequence":"additional","affiliation":[{"name":"Clinique Sp\u00e9cialis\u00e9e en Allergie de la Capitale  Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Nolte","sequence":"additional","affiliation":[{"name":"ALK  Bedminster New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eike","family":"Wuestenberg","sequence":"additional","affiliation":[{"name":"ALK\u2010Abell\u00f3 A\/S  H\u00f8rsholm Denmark"},{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine (and University Hospital) Carl Gustav Carus Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00e9mi","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Clinique Sp\u00e9cialis\u00e9e en Allergie de la Capitale  Qu\u00e9bec Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/623474"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.11.035"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.03.019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.06.044"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.12.1001"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02761.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1939-4551-7-6"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.1017468"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2017.1302306"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2019.07.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.04.071"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01611.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02510.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2021.706589"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.026"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.03.039"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1303"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04626-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.08.017"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.12.025"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-10-55"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.06.036"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200528110-00006"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.01.037"}],"container-title":["Clinical &amp; 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