{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:24:35Z","timestamp":1788330275184,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Benralizumab has been reported to lead to clinical remission of severe eosinophilic asthma (SEA) at 1\u2009year in some patients. However, whether this is maintained over a longer term remains unclear. Additionally, the impact of pulmonary and extrapulmonary comorbidities on the ability to meet remission is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical outcomes including remission of SEA with benralizumab at 1 and 2\u2009years were assessed retrospectively in a real\u2010world UK multi\u2010centre severe asthma cohort. The presence of clinically relevant pulmonary and extrapulmonary comorbidities associated with respiratory symptoms was recorded. Analyses to identify factors associated with the ability to meet remission were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 276 patients with SEA treated with benralizumab including 113 patients who had switched from a previous biologic to benralizumab were included. Overall, clinical remission was met in 17% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931\/186) and 32% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943\/133) of patients at 1 and 2\u2009years, respectively. This increased to 28% at 1\u2009year and 49% at 2\u2009years once patients with pulmonary and\/or extrapulmonary comorbidities were excluded. Body mass index (BMI) and maintenance OCS (mOCS) use demonstrated a negative association with clinical remission at 1 (BMI: OR: 0.89, 95% CI: 0.82\u20130.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01; mOCS: OR: 0.94, 95% CI: 0.89\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and 2\u2009years (BMI: OR: 0.93, 95% CI: 0.87\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05; mOCS: OR: 0.95, 95% CI: 0.89\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this long\u2010term, real\u2010world study, patients with SEA demonstrated the ability to meet and sustain clinical remission when treated with benralizumab. The presence of comorbidities including obesity, which are known to be independently associated with respiratory symptoms, reduced the likelihood of meeting clinical remission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.14544","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T21:33:26Z","timestamp":1722461606000},"page":"734-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Overcoming Barriers to Remission in Severe Eosinophilic Asthma: Two\u2010Year Real\u2010World Data With Benralizumab"],"prefix":"10.1111","volume":"54","author":[{"given":"David\u00a0J.","family":"Jackson","sequence":"first","affiliation":[{"name":"Guy's Severe Asthma Centre Guy's &amp; St Thomas' NHS Trust  London UK"},{"name":"School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Burhan","sequence":"additional","affiliation":[{"name":"Liverpool University Hospitals NHS Foundation Trust  Liverpool UK"},{"name":"University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0150-138X","authenticated-orcid":false,"given":"Hitasha","family":"Rupani","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul\u00a0E.","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"St. Bartholomew's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-9506","authenticated-orcid":false,"given":"Ian\u00a0J.","family":"Clifton","sequence":"additional","affiliation":[{"name":"University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaib","family":"Faruqi","sequence":"additional","affiliation":[{"name":"Hull University Teaching Hospitals  Hull UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaideep","family":"Dhariwal","sequence":"additional","affiliation":[{"name":"Guy's Severe Asthma Centre Guy's &amp; St Thomas' NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pujan","family":"Patel","sequence":"additional","affiliation":[{"name":"Royal Brompton and Harefield Hospitals  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamsin","family":"Morris","sequence":"additional","affiliation":[{"name":"AstraZeneca UK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Lipworth","sequence":"additional","affiliation":[{"name":"AstraZeneca UK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Watt","sequence":"additional","affiliation":[{"name":"AstraZeneca UK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Lupton","sequence":"additional","affiliation":[{"name":"AstraZeneca UK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabada","family":"Dube","sequence":"additional","affiliation":[{"name":"AstraZeneca UK  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Hickey","sequence":"additional","affiliation":[{"name":"OPEN Health  Marlow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra\u00a0M.","family":"Nanzer","sequence":"additional","affiliation":[{"name":"Guy's Severe Asthma Centre Guy's &amp; St Thomas' NHS Trust  London UK"},{"name":"School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.08.042"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(21)00352\u20100"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.04.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00415-0"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00331-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.12.019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00819-2023"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.02.014"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/02770903.2015.1101134"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5525"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8852"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2020.02.009"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.05.047"},{"issue":"23","key":"e_1_2_11_16_1","first-page":"253","article-title":"Clinical Response and Remission in Patients With Severe Asthma Treated With Biologic Therapies","volume":"165","author":"Hansen S.","year":"2023","journal-title":"Chest"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02539-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02439-w"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01521\u20102023"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00245-2023"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax\u20102023\u2010220512"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00004-7"}],"container-title":["Clinical &amp; 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