{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:13:31Z","timestamp":1791922411731,"version":"4.3.4"},"reference-count":84,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Wheat is a well\u2010known elicitor of food allergy, but epidemiological data are limited. The aim of this study was to investigate the prevalence of wheat allergy in an unselected population of adults and adolescents and to characterise the clinical features of this cohort, as well as those of patients who experienced wheat\u2010induced anaphylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A population\u2010based cross\u2010sectional study was conducted. Fifteen thousand individuals aged 12\u201380\u2009years were randomly selected, and a standardised questionnaire was applied. If symptoms after wheat consumption were reported, telephone interviews were conducted. In the case of suspected type 1 wheat allergy, a skin prick test, specific immunoglobulin E (sIgE) and oral food challenge (OFC) were performed. The prevalence of self\u2010reported wheat sensitivity and wheat allergy was determined after data extrapolation. For the assessment of severe wheat allergy\u2010associated symptoms, a cohort from the European Anaphylaxis Registry was analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The questionnaire was answered by 1770 individuals, of whom 13.1% reported symptoms due to the consumption of foods containing wheat. Following telephone interviews (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009105) and clinical diagnostics (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), type 1 sensitisation to wheat was confirmed in 8 individuals, and 2 subjects were finally diagnosed with an IgE\u2010mediated wheat allergy. After extrapolation, the prevalence of confirmed wheat allergy in the German population reached 0.25% [95% CI 0.08\u20130.9]. Self\u2010reported wheat sensitivity was predominantly seen in females (71%), with local gastrointestinal and non\u2010specific symptoms. This contrasted with wheat\u2010induced anaphylaxis, where less than half occurred in females, and symptoms were mainly skin, cardiovascular or respiratory.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a population with widespread wheat consumption, self\u2010reported wheat sensitivity was common in adults and adolescents, but confirmed wheat allergy was rare. The distinct symptom profiles allow physicians to easily differentiate these entities. Dissemination of our findings may help to improve knowledge of the low prevalence of wheat allergy and may support the reduction of unnecessary dietary restrictions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.70017","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T01:44:42Z","timestamp":1740015882000},"page":"319-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and Clinical Symptoms of Wheat Allergy in Adults and Adolescents in Central Europe"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6955-4872","authenticated-orcid":false,"given":"A.","family":"Neyer","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergy Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"D\u00f6lle\u2010Bierke","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergy Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"H\u00f6fer","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergy Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gr\u00fcnhagen","sequence":"additional","affiliation":[{"name":"Division of 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