{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:16:21Z","timestamp":1789067781455,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The introduction of biologics, such as benralizumab (an anti\u2010IL\u20105 receptor \u03b1 humanised monoclonal antibody), has made remission a feasible goal for patients with severe eosinophilic asthma (SEA). However, there are remaining research gaps and no clear consensus on the definition of remission. We consolidated\n                    <jats:italic>post hoc<\/jats:italic>\n                    remission data from clinical trials and real\u2010world studies of benralizumab in patients with SEA to gather insights on: testing different definitions; predictors of remission; the effect of comorbidities on achieving remission; remission and background medication reduction; long\u2010term remission patterns with benralizumab; and remission in a real\u2010life setting. In the SIROCCO and CALIMA Phase 3 randomised studies, patients with remission had higher baseline median blood eosinophil counts, were more likely to have a FEV\n                    <jats:sub>1<\/jats:sub>\n                    of \u2265 65% predicted, had fewer exacerbations within 12\u2009months and had lower mean ACQ\u20106 scores. Compared with the overall population, patients with a history of nasal polyps were also more likely to achieve remission with benralizumab. Analyses of the BORA and MELTEMI extension studies showed that in the longer term, once remission is achieved with benralizumab, patients are likely to remain in remission with continued treatment. In the open\u2010label, single\u2010arm ANDHI\u2010In Practice and PONENTE studies, patients achieving remission had a shorter median time since asthma diagnosis, higher median age at asthma onset and lower median ACQ\u20106 scores. The SHAMAL study and the Phase 3b ANDHI\u2010In Practice substudy demonstrate that remission is maintained with benralizumab even when patients reduce their background medication. Finally, the XALOC\u20101 real\u2010world study highlights how patients with lower BMI are more likely to achieve remission with benralizumab. These findings demonstrate that achieving remission in patients with SEA is feasible with benralizumab and, in turn, inform future directions for research and treatment that includes a promising shift towards a new era of treat\u2010to\u2010target. This manuscript was supported by AstraZeneca, the manufacturer of benralizumab.\n                  <\/jats:p>","DOI":"10.1111\/cea.70083","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:20:40Z","timestamp":1748586040000},"page":"521-531","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Advancing Remission in Severe Asthma With Benralizumab: Latest Findings, Current Perspectives and Future Direction"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-9084","authenticated-orcid":false,"given":"Renaud","family":"Louis","sequence":"first","affiliation":[{"name":"University of Liege, GIGA I3 Research Group and Centre Hospitalier Universitaire of Li\u00e8ge, Department of Pneumology CHU Liege, Belgium  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-9348","authenticated-orcid":false,"given":"Marek","family":"Lommatzsch","sequence":"additional","affiliation":[{"name":"Department of Pneumology University of Rostock  Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2299-868X","authenticated-orcid":false,"given":"David J.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Guy's Severe Asthma Centre Guy's &amp; St Thomas NHS Trust  London UK"},{"name":"School of Immunology &amp; Microbial Sciences King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9707-4986","authenticated-orcid":false,"given":"Andrew","family":"Menzies\u2010Gow","sequence":"additional","affiliation":[{"name":"BioPharmaceutials Medical AstraZeneca  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9898-907X","authenticated-orcid":false,"given":"Anat","family":"Shavit","sequence":"additional","affiliation":[{"name":"BioPharmaceutials Medical AstraZeneca  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4422-9949","authenticated-orcid":false,"given":"David","family":"Cohen","sequence":"additional","affiliation":[{"name":"Late\u2010Stage Respiratory &amp; Immunology AstraZeneca  Gaithersburg Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-6362","authenticated-orcid":false,"given":"Flavia C. L.","family":"Hoyte","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine National Jewish Health  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2239-5029","authenticated-orcid":false,"given":"Stephanie","family":"Korn","sequence":"additional","affiliation":[{"name":"Thoraxklinik Heidelberg and IKF Pneumologie Mainz  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00202013"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00246"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215168"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.10.053"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.04.013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000537833"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01874-2019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00004013"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.10.046"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.12.006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00331-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.149765"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X17720366"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-201110002-01210"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00304-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.11.2006165"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.01.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000001068"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.08.609"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(23)00415-0"},{"issue":"8","key":"e_1_2_11_23_1","first-page":"461","article-title":"Diagnosis and Treatment of Asthma: A Guideline for Respiratory Specialists 2023 [in German]","volume":"77","author":"Lommatzsch M.","year":"2023","journal-title":"Pneumologie"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.opresp.2023.100277"},{"key":"e_1_2_11_25_1","unstructured":"Global Initiative for Asthma. \u201cGlobal Strategy for Asthma Management and Prevention (2024 Update) \u201dhttps:\/\/ginasthma.org\/wp\u2010content\/uploads\/2024\/05\/GINA\u20102024\u2010Strategy\u2010Report\u201024_05_22_WMS.pdf."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2024.01.044"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02284-5"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31324-1"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31322-8"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(18)30406\u20105"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.07.058"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.03.009"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00352-0"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01521-2023"},{"issue":"112","key":"e_1_2_11_35_1","first-page":"485","article-title":"Clinical Remission in Patients With Severe Eosinophilic Asthma With Benralizumab According to Body Mass Index Status in an Integrated Analysis of the Real\u2010World XALOC\u20101 Study","volume":"78","author":"Jackson D. J.","year":"2023","journal-title":"Allergy"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14544"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.08.156"},{"issue":"67","key":"e_1_2_11_38_1","article-title":"Durability of Benralizumab\u2010Induced Remission in Severe Asthma: An Analysis of the BORA Study","volume":"62","author":"Lommatzsch M.","year":"2023","journal-title":"European Respiratory Journal"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.09.140"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02583-2021"},{"issue":"4","key":"e_1_2_11_41_1","first-page":"775","article-title":"Review: Treat to Target in Rheumatoid Arthritis: Fact, Fiction, or Hypothesis? Arthritis","volume":"66","author":"Solomon D. H.","year":"2014","journal-title":"Rheumatol"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1591443"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad086"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.70083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cea.70083","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.70083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T11:19:46Z","timestamp":1771327186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.70083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,30]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/cea.70083"],"URL":"https:\/\/doi.org\/10.1111\/cea.70083","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,30]]},"assertion":[{"value":"2024-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}