{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:35Z","timestamp":1787013995721,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gaining a better understanding of the risk factors for severe anaphylaxis represents a crucial challenge for physicians. This survey aimed to analyse cases of severe food anaphylaxis and assess potential risk factors for severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed food anaphylaxis cases recorded by the French\u2010speaking Allergy\u2010Vigilance Network (2002\u20132021) and compared the main characteristics of grade 3 (Ring classification) and grade 4 cases using univariate and multivariate statistical analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 2621 food anaphylaxis cases reported, 731 (27.9%) were considered severe (grade 3,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009687 [94%] and grade 4,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200944 [6%]; 19 deaths). Overall, 56.1% of cases were adults (mean age: 28.3\u2009years) and 53.7% were male. The most frequent triggers were peanut (13.9%), wheat (9.4%), cashew (5.8%), shrimp (5.3%), and cow's milk (4.6%). More grade 4 anaphylaxis cases occurred in children than in adults (26 vs. 18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). In univariate analysis, individuals with grade 4 anaphylaxis were more likely to have a history of allergy to the culprit food (71.1% vs. 42.1%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), asthma diagnosis (59.5% vs. 30.4%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and peanut as the culprit food (34.1% vs. 12.6%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariate analysis, factors predictive of grade 4 anaphylaxis were asthma diagnosis (OR [95% CI]: 3.41 [1.56\u20137.44];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) and peanut as the culprit trigger (OR [95% CI]: 3.46 [1.28\u20139.34];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data highlight the risk factors for severe food anaphylaxis, notably a history of asthma and peanut as the culprit food. These individuals should benefit from personalised management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.70089","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:29:09Z","timestamp":1748554149000},"page":"532-540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk Factors for Fatal and Near\u2010Fatal Food Anaphylaxis: Analysis of the Allergy\u2010Vigilance Network Database"],"prefix":"10.1111","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-6385","authenticated-orcid":false,"given":"Guillaume","family":"Pouessel","sequence":"first","affiliation":[{"name":"CH Roubaix, Department of Paediatrics Children's Hospital  Roubaix France"},{"name":"CHU Lille, Paediatric Pulmonology and Allergy Department P\u00f4le Enfant, H\u00f4pital Jeanne de Flandre  Lille France"},{"name":"Univ Lille, ULR 2694: METRICS  Lille France"},{"name":"Allergy\u2010Vigilance Network  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Egea","sequence":"additional","affiliation":[{"name":"CH Roubaix, Department of Paediatrics Children's Hospital  Roubaix France"},{"name":"CHU Lille, Paediatric Pulmonology and Allergy Department P\u00f4le Enfant, H\u00f4pital Jeanne de Flandre  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2492-9864","authenticated-orcid":false,"given":"Amandine","family":"Divaret\u2010Chauveau","sequence":"additional","affiliation":[{"name":"Allergy\u2010Vigilance Network  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Paediatric Allergology, Children's Medicine CHRU  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7124-7736","authenticated-orcid":false,"given":"Pascale","family":"Beaumont","sequence":"additional","affiliation":[{"name":"Allergy\u2010Vigilance Network  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Medical Office  Saint Maur des Foss\u00e9s France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00e9na","family":"Bradatan","sequence":"additional","affiliation":[{"name":"Allergy\u2010Vigilance Network  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Department of Paediatrics CHRU  Namur Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Dumond","sequence":"additional","affiliation":[{"name":"Allergy\u2010Vigilance Network  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Paediatric Allergology, Children's Medicine CHRU  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7938-4091","authenticated-orcid":false,"given":"R\u00e9my","family":"Diesnis","sequence":"additional","affiliation":[{"name":"Emergency Department, General Hospital of Roubaix; Clinic Research Unit General Hospital of Roubaix  Roubaix France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-9367","authenticated-orcid":false,"given":"S\u00e9lina","family":"Tscheiller","sequence":"additional","affiliation":[{"name":"Allergy\u2010Vigilance Network  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Van der Brempt","sequence":"additional","affiliation":[{"name":"Allergop\u00f4le Clinique Saint\u2010Luc, Bouge  Namur Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9260-8977","authenticated-orcid":false,"given":"Camille","family":"Braun","sequence":"additional","affiliation":[{"name":"Allergy\u2010Vigilance Network  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"Paediatric Pulmonology and Allergology Department, Paediatric Cystic Fibrosis Centre H\u00f4pital Femme M\u00e8re Enfant, Hospices Civils de Lyon  Bron France"},{"name":"Centre International de Recherche en Infectiologie INSERM U1111  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sabouraud\u2010Leclerc","sequence":"additional","affiliation":[{"name":"Allergy\u2010Vigilance Network  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"},{"name":"General and Specialised Paediatrics, Department, American Hospital Reims University Hospital  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.031"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14434"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.09.044"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.05.015"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15318"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jahd.2024.100018"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13717"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15645"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1303"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02737644"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.03.048"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14683"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.10.021"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12748"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.04.025"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13483"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13380"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13287"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12924"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2015.01.006"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.06.035"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.01.006"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12317"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.11124\/JBIES-21-00182"}],"container-title":["Clinical &amp; 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