{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:51:21Z","timestamp":1782978681481,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Prospective real\u2010world data concerning the early and sustained effects of benralizumab on asthma control in patients with severe eosinophilic asthma (\n                      <jats:styled-content style=\"fixed-case\">SEA<\/jats:styled-content>\n                      ) is lacking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">XALOC<\/jats:styled-content>\n                      \u20102 is a prospective, observational, multi\u2010national, real\u2010world study in adults with\n                      <jats:styled-content style=\"fixed-case\">SEA<\/jats:styled-content>\n                      treated with benralizumab. This integrated analysis assessed Asthma Control Questionnaire (\n                      <jats:styled-content style=\"fixed-case\">ACQ<\/jats:styled-content>\n                      ) scores, achievement of 3\u2010component clinical remission (which included well\u2010controlled symptoms [\n                      <jats:styled-content style=\"fixed-case\">ACQ<\/jats:styled-content>\n                      score \u2264\u20090.75], no exacerbations, and no use of maintenance oral corticosteroids [\n                      <jats:styled-content style=\"fixed-case\">mOCS<\/jats:styled-content>\n                      ]), and other clinical outcomes, over a 12\u2010month baseline period and up to Week 56. Associations between remission status and key baseline characteristics were also assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      535 patients were included. Median (interquartile range)\n                      <jats:styled-content style=\"fixed-case\">ACQ<\/jats:styled-content>\n                      score at baseline was 3.0 (2.2\u20133.8). At Week 1, 58.0% (282\/486) of patients had\n                      <jats:styled-content style=\"fixed-case\">ACQ<\/jats:styled-content>\n                      score reductions of \u2265\u20090.5 points (minimal clinically important difference [\n                      <jats:styled-content style=\"fixed-case\">MCID<\/jats:styled-content>\n                      ]) and 35.0% (170\/486) had reductions of \u2265\u20091 point (2\u00d7\n                      <jats:styled-content style=\"fixed-case\">MCID<\/jats:styled-content>\n                      ). By Week 56, these increased to 78.6% (276\/351) and 62.1% (218\/351), respectively. Improved asthma control after benralizumab initiation was similar irrespective of previous biologic use status. By Week 56, clinical remission criteria were achieved in 26.7% (70\/262) of patients versus 0% (0\/374) at baseline. No\n                      <jats:styled-content style=\"fixed-case\">mOCS<\/jats:styled-content>\n                      use, lower body mass index, better asthma symptom control and higher peak blood eosinophil count at baseline were associated with meeting 3\u2010component clinical remission criteria at Week 56.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010world patients receiving benralizumab showed early and sustained improvements in asthma symptoms, regardless of previous biologic use. More than a quarter of patients achieved clinical asthma remission after 1\u2009year of benralizumab treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.70162","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T02:49:58Z","timestamp":1761792598000},"page":"212-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early and Sustained Asthma Control and Remission in Real\u2010World Patients With Severe Eosinophilic Asthma Treated With Benralizumab:\n                    <scp>XALOC<\/scp>\n                    \u20102"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-8450","authenticated-orcid":false,"given":"Erika","family":"Penz","sequence":"first","affiliation":[{"name":"University of Saskatchewan  Saskatoon Saskatchewan 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