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Severe asthma, defined as asthma remaining uncontrolled despite adherence to optimised high\u2010dose inhaled corticosteroids\/long\u2010acting \u03b22\u2010agonist therapy and management of contributory factors, worsens upon dose reduction. In China, 3.4%\u20138.3% of patients with asthma have severe asthma, characterised by heterogeneity, frequent exacerbations, and considerable medical and economic burdens. Recent advances in the understanding of its pathogenesis, especially the development of biologics, have enabled new treatment strategies. This review incorporates recent progress from China regarding the epidemiology, pathogenesis, and biologic therapy for severe asthma.<\/jats:p>","DOI":"10.1111\/cea.70166","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:20:42Z","timestamp":1761391242000},"page":"147-166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management and Research Progress of Severe Asthma in China"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0162-725X","authenticated-orcid":false,"given":"Xiaoying","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"China\u2010Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong\u2010Hong Kong\u2010Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2932-5590","authenticated-orcid":false,"given":"Rui","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, 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First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"China\u2010Portugal Artificial Intelligence and Public Health Technologies Joint Laboratory, Guangdong\u2010Hong Kong\u2010Macao Joint Laboratory of Respiratory Infectious Diseases, Guangdong Provincial Key Laboratory of Respiratory Disease Research, Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou National Laboratory  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5376-8230","authenticated-orcid":false,"given":"Ruchong","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Joint International Research Laboratory of Respiratory Health, Guangdong Basic Research Center of Excellence for Respiratory Medicine, Department of Allergy and Clinical Immunology, Guangzhou 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