{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T15:13:23Z","timestamp":1778253203484,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100022830","name":"Euroimmun Medizinische Labordiagnostika","doi-asserted-by":"publisher","award":["118583"],"award-info":[{"award-number":["118583"]}],"id":[{"id":"10.13039\/100022830","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Digital symptom monitoring via e\u2010Diary apps can support the diagnosis and management of chronic diseases with trigger\u2010induced exacerbations such as pollen allergies. Attrition is a major challenge for continuous e\u2010Diary usage with an unsupervised approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate adherence to e\u2010Diary reporting, its early determinants and predictors in a blended care setting among pollen allergic patients with heterogeneous cultural backgrounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The @IT.2020 observational multicenter study recruited patients with diagnosed seasonal allergic rhinitis from seven Southern European\/Mediterranean countries. Baseline characteristics were investigated through questionnaires, skin prick tests and serum specific IgE measurements. The study doctors asked patients to record their allergy symptoms via e\u2010Diary (AllergyMonitor, TPS) daily during the clinically relevant season of pollination and increased mould concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 815 patients (467 adults, 348 children), the average prescribed e\u2010Diary recording period was 106 (SD 47.1) days, with an average completion rate of 75.2% (SD 21.2%). Children (\u2265\u200910\u2009years) filled 73.8% (95% CI 68.1\u201379.4) of prescribed days without parental support. We identified a stable \u2018higher\u2019 and a more variable \u2018lower\u2019 adherence cluster. Adherence was weakly associated with disease severity, but not with age, gender, country, education or digital literacy. Short\u2010term (first 3\u2009weeks) adherence was strongly associated with long\u2010term adherence (partial\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.387,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), with 87.6% of lower adherent patients remaining poorly adherent beyond 3\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a blended care setting, adherence to e\u2010Diary compilation among pollen allergic patients is high, irrespective of age and cultural background. Early identification of lower adherence is possible and might inform early interventions to improve patient adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.70203","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T06:38:57Z","timestamp":1769236737000},"page":"526-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Detection of Lower Adherence to Long\u2010Term e\u2010Diary Recording: A Checkpoint to Target Early Educational Intervention in Seasonal Allergic Rhinitis?"],"prefix":"10.1111","volume":"56","author":[{"given":"S.","family":"Dramburg","sequence":"first","affiliation":[{"name":"Department of Pediatric Respiratory Care, Immunology and Intensive Care Medicine Charit\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Hernandez Toro","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Care, Immunology and Intensive Care Medicine Charit\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Institute of Biometry and Clinical Epidemiology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Grittner","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Clinical Epidemiology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Tripodi","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Unit Sandro Pertini Hospital  Rome Italy"},{"name":"Allergolology Service, Policlinico Casilino  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Arasi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Respiratory Care, Immunology and Intensive Care Medicine Charit\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Pediatric Allergology Unit, Department of Pediatric Medicine Bambino Ges\u00f9 Children\u00b4s Research Hospital (IRCCS)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Acar \u015eahin","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1715-3022","authenticated-orcid":false,"given":"X.","family":"Aggelidis","sequence":"additional","affiliation":[{"name":"Allergy Unit, 2nd Department of Dermatology and Venereology National and Kapodistrian University of Athens, University Hospital \u2018Attikon\u2019  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Barbalace","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\u2014Allergy Unit University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bourgoin","sequence":"additional","affiliation":[{"name":"Department of Pneumonology and Allergy La Timone Hospital, APHM, Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Bregu","sequence":"additional","affiliation":[{"name":"Department of Allergology and Clinical Immunology UHC Mother Teresa, Medical University Tirana  Tirana Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Brighetti","sequence":"additional","affiliation":[{"name":"Department of Biology Tor Vergata University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Caeiro","sequence":"additional","affiliation":[{"name":"MED\u2010 Mediterranean Institute for Agriculture, Environment and Development &amp; CHANGE\u2014Global Change and Sustainability Institute, Institute for Advanced Studies and Research University of \u00c9vora  \u00c9vora Portugal"},{"name":"Portuguese Society of Allergology and Clinical Immunology  Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Caglayan Sozmen","sequence":"additional","affiliation":[{"name":"Fenerbahce University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3054-5338","authenticated-orcid":false,"given":"L.","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics\u2014Allergy Unit University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Charpin","sequence":"additional","affiliation":[{"name":"Department of Pneumonology and Allergy La Timone Hospital, APHM, Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Couto","sequence":"additional","affiliation":[{"name":"Immunoallergology, Hospital CUF Trindade  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Delgado","sequence":"additional","affiliation":[{"name":"Basic and Clinical Immunology Unit, Department of Pathology, Faculty of Medicine University of Porto  Porto Portugal"},{"name":"RISE\u2010Health Faculty of Medicine of the University of Porto  Porto Portugal"},{"name":"Allergy Unit Instituto and Hospital CUF Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Di Rienzo Businco","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Unit Sandro Pertini Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Dimier","sequence":"additional","affiliation":[{"name":"Department of Pneumonology and Allergy La Timone Hospital, APHM, Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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