{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:43:19Z","timestamp":1783647799294,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7252111"],"award-info":[{"award-number":["7252111"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370041"],"award-info":[{"award-number":["82370041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In China, therapeutic options are limited by the narrow availability of allergen preparations, with house dust mite (HDM) allergen immunotherapy (AIT) as the main choice for most patients. However, polysensitization is highly prevalent, and the benefit of HDM AIT in such patients remains uncertain. The study aims to evaluate the effectiveness of single\u2010allergen HDM AIT on both perennial and coexisting allergen\u2010specific symptoms in polysensitised allergic rhinitis (AR) patients and to explore predictors of treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a multicenter retrospective cohort study including 81 patients with AR who were polysensitised to HDM and at least one other inhalant allergen (e.g., pollens, mould or animal dander). All participants received HDM subcutaneous immunotherapy (SCIT) for 12 to 36\u2009months. Baseline characteristics, including serum allergen\u2010specific IgE (sIgE) levels and comorbidities, were collected. Symptom severity was assessed using the Visual Analog Scale (VAS), and treatment response was defined as a \u2265\u200930% reduction in VAS scores from baseline. Statistical comparisons between responders and non\u2010responders were conducted using Fisher's exact test for categorical variables and Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      tests for continuous data. Firth logistic regression was used to identify predictors of treatment response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall response rate for perennial symptoms was 68.8%, and varied in patients with co\u2010existing allergies: 72.7% for moulds, 70.0% for animal dander, 65.5% for tree pollen, 70.2% for weed pollens. Allergen\u2010specific symptom response rates varied across allergens: 68.2% for moulds, 30.0% for animal dander, 56.7% for tree pollens, 74.5% for weed pollens. Higher sIgE levels to HDM and mould were significantly associated with lower response rates in patients co\u2010sensitised to both. A predictive model incorporating both sIgEs showed good specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Single\u2010allergen HDM AIT is effective in many polysensitised AR patients; however, its efficacy varies by coexisting allergen type and sIgE level. Patients co\u2010sensitised to mould with high HDM and mould sIgE appeared to have poorer outcomes. These preliminary findings require confirmation in larger prospective studies to guide tailored AIT strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.70229","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T23:50:22Z","timestamp":1770162622000},"page":"629-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness and Predictors of House Dust Mite Subcutaneous Immunotherapy in Polysensitised Patients With Allergic Rhinitis: A Multicentre Retrospective Study"],"prefix":"10.1111","volume":"56","author":[{"given":"Zhouxian","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2640-7604","authenticated-orcid":false,"given":"Shengyang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases  Beijing China"},{"name":"Eight\u2010Year Medical Doctor Program, Peking Union Medical College Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment on Allergic Diseases  Beijing 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Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshang","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Allergy Children's Hospital of the Capital Institute of Pediatrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Allergy Children's Hospital of the Capital Institute of Pediatrics  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease Shenzhen Children's Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease Shenzhen Children's Hospital  Shenzhen 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