{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:10:49Z","timestamp":1783728649402,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Chronic rhinosinusitis with nasal polyps (CRSwNP) can be classified into Eosinophilic CRSwNP (ECRSwNP) and non\u2010Eosinophilic CRSwNP (nECRSwNP) based on eosinophilic infiltration in nasal polyps. However, no consensus criteria exist for eosinophilic infiltration in nasal polyps, including different cutoffs for eosinophil (EOS) counts or different EOS proportions among inflammatory cells.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Inferior turbinate (IT) tissues from controls (\n n<\/jats:italic>\n \u2009=\u200927) and nasal polyp (NP) tissues from ECRSwNPs (\n n<\/jats:italic>\n \u2009=\u200950) were collected. ECRSwNPs (\n n<\/jats:italic>\n \u2009=\u200938) underwent 2\u2010year post\u2010FESS follow\u2010up. Clinical assessments (SNOT\u201022, Lund\u2010Mackay, Lund\u2010Kennedy scores), eosinophil indicators (polyp\/blood EOS counts, EETs area), and Th2 cytokines pre\/post\u2010FESS were recorded for correlation analysis and prognostic model building. Subsequently, functional nanosheets TLPG\n A<\/jats:sub>\n targeting EETs were synthesized and tested for EETs clearance in human EOS, epithelial cell models, and NP models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Our findings demonstrated positive correlations between EETs area and ECRSwNP severity, including Lund\u2010Mackay CT scores (\n r<\/jats:italic>\n \u2009=\u20090.72,\n p<\/jats:italic>\n \u2009<\u20090.001), Lund\u2010Kennedy Endoscopic score (\n r<\/jats:italic>\n \u2009=\u20090.57,\n p<\/jats:italic>\n \u2009<\u20090.001), IL\u20104 (\n r<\/jats:italic>\n \u2009=\u20090.50,\n p<\/jats:italic>\n \u2009<\u20090.001), IL\u20105 (\n r<\/jats:italic>\n \u2009=\u20090.50,\n p<\/jats:italic>\n \u2009<\u20090.001), IL\u201013 (\n r<\/jats:italic>\n \u2009=\u20090.39,\n p<\/jats:italic>\n \u2009<\u20090.01), and Periostin (\n r<\/jats:italic>\n \u2009=\u20090.34,\n p<\/jats:italic>\n \u2009<\u20090.05). And we first demonstrated that increased preoperative EETs area predicts both impaired mucosal recovery and elevated nasal polyp uncontrolled risk within 2\u2009years post\u2010FESS. Furthermore, we developed novel nanosheets TLPG\n A<\/jats:sub>\n and demonstrated that TLPG\n A<\/jats:sub>\n effectively scavenges EETs and alleviates the type 2 inflammatory cascade in human nasal polyp tissues and epithelial cell model.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings highlight the potential of EETs and EOS morphology in assessing preoperative ECRSwNP severity and predicting postoperative prognosis. Moreover, this also supports TLPG\n A<\/jats:sub>\n as a promising therapeutic approach for managing ECRSwNP with high EETs levels.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cea.70235","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:34:52Z","timestamp":1770942892000},"page":"650-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Significance of Eosinophil Extracellular Traps in Chronic Rhinosinusitis and Innovative Nanosheets\u2010Based Clearance Therapy"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1233-8845","authenticated-orcid":false,"given":"Changhui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou Guangdong China"},{"name":"Otorhinolaryngology Institute Sun Yat\u2010sen University Guangzhou 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Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou Guangdong China"},{"name":"Otorhinolaryngology Institute Sun Yat\u2010sen University Guangzhou Guangdong China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6124-6619","authenticated-orcid":false,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou Guangdong China"},{"name":"Otorhinolaryngology Institute Sun Yat\u2010sen University Guangzhou Guangdong China"},{"name":"Guangzhou Key Laboratory of Otorhinolaryngology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou Guangdong China"},{"name":"Guangxi Hospital Division of the First Affiliated Hospital Sun 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