{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:07:43Z","timestamp":1789567663602,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100031004","name":"KalVista Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031004","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with hereditary angioedema (HAE) experience anxiety from the unpredictable nature of attacks and the burden of parenteral on\u2010demand therapies, potentially leading to delays or avoidance of treatment. This analysis assessed factors associated with anxiety during attacks and the impact of oral sebetralstat versus placebo on anxiety in the KONFIDENT trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants in the randomised, double\u2010blind, phase 3 KONFIDENT trial (NCT05259917) treated attacks with sebetralstat 300\u2009mg, 600\u2009mg or placebo as early as possible after onset. Anxiety was recorded at treatment administration, every 0.5\u2009h thereafter through 4\u2009h, hourly from 5 to 12\u2009h and every 2\u2009h from 14 to 24\u2009h using an 11\u2010point modified General Anxiety Numeric Rating Scale (GA\u2010NRS). Prespecified exploratory endpoints assessed in all attacks and in attacks rated as inducing moderate\u2010to\u2010extreme anxiety (GA\u2010NRS \u2265\u20094) included cumulative GA\u2010NRS score and meaningful reduction in anxiety (defined as \u2265\u20092\u2010point reduction in GA\u2010NRS for \u2265\u20092 consecutive timepoints); least squares mean change from treatment administration in GA\u2010NRS at 4 and 12\u2009h was also assessed. This study was sponsored by KalVista Pharmaceuticals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 115 (44%) attacks were rated as inducing moderate\u2010to\u2010extreme anxiety. Female sex, shorter time since HAE diagnosis and greater attack severity were associated with greater anxiety at treatment administration. Reduction in cumulative anxiety after sebetralstat use was significantly greater versus placebo. The time to meaningful reduction in anxiety endpoint showed agreement with time to beginning of symptom relief, reduction in attack severity and complete attack resolution endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Moderate\u2010to\u2010extreme anxiety was common in HAE attacks. Reduction in anxiety was significantly greater in attacks treated with sebetralstat compared with placebo.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cea.70241","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:23:01Z","timestamp":1772958181000},"page":"739-747","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks"],"prefix":"10.1111","volume":"56","author":[{"given":"Timothy","family":"Craig","sequence":"first","affiliation":[{"name":"Departments of Medicine, Pediatrics, Maternal\u2010Fetal Medicine, Obstetrics and Gynecology, and Biomedical Sciences Penn State University  Hershey Pennsylvania USA"},{"name":"Vinmec International Hospital  Times City Hanoi Vietnam"},{"name":"Vin\u2010University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emel","family":"Ayg\u00f6ren\u2010P\u00fcrs\u00fcn","sequence":"additional","affiliation":[{"name":"University Hospital Frankfurt, Goethe University Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"University of Cincinnati College of Medicine and Bernstein Clinical Research Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula J.","family":"Busse","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Clinical Immunology Icahn School of Medicine at Mount Sinai School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Caballero","sequence":"additional","affiliation":[{"name":"Servicio de Alergia, Hospital Universitario La Paz, Hospital La Paz Health Research Institute (IdiPAZ) Biomedical Research Network on Rare Diseases (CIBERER U754)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9036-3723","authenticated-orcid":false,"given":"Danny M.","family":"Cohn","sequence":"additional","affiliation":[{"name":"Amsterdam University Medical Center, University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Guilarte","sequence":"additional","affiliation":[{"name":"Department of Allergy Hospital Universitari Vall D'hebron, Vall D'hebron Research Institute (VHIR)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"Farkas","sequence":"additional","affiliation":[{"name":"Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7812-9125","authenticated-orcid":false,"given":"Douglas H.","family":"Jones","sequence":"additional","affiliation":[{"name":"Rocky Mountain Allergy Tanner Clinic  Layton Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorena","family":"Kiani\u2010Alikhan","sequence":"additional","affiliation":[{"name":"Division of Infection and Immunity University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4455-7356","authenticated-orcid":false,"given":"Michael E.","family":"Manning","sequence":"additional","affiliation":[{"name":"Internal Medicine UA College of Medicine\u2010Phoenix  Phoenix Arizona USA"},{"name":"Allergy, Asthma, &amp; Immunology Associates, Ltd  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4121-481X","authenticated-orcid":false,"given":"Marcus","family":"Maurer","sequence":"additional","affiliation":[{"name":"Institute of Allergology, Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4tsmedizin Berlin and Humboldt\u2010Universit\u00e4t Zu Berlin  Berlin Germany"},{"name":"Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Immunology and Allergology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Riedl","sequence":"additional","affiliation":[{"name":"University of California\u2014San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinisa","family":"Savic","sequence":"additional","affiliation":[{"name":"The Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. James","family":"Wedner","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, John T. Milliken Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1736-2756","authenticated-orcid":false,"given":"Patrick F. 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