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It is currently approved by both the Food and Drug Administration and the European Medicines Agency for multiple indications, including moderate\u2010to\u2010severe atopic dermatitis (from 6\u2009months of age), add\u2010on maintenance therapy for moderate\u2010to\u2010severe asthma with T2 inflammation (\u2265\u20096\u2009years), eosinophilic esophagitis (\u2265\u20091\u2009year and \u2265\u200915\u2009kg), chronic rhinosinusitis with nasal polyps (\u2265\u200912\u2009years in the United States and \u2265\u200918\u2009years in Europe), and chronic spontaneous urticaria (\u2265\u200912\u2009years in the United States and \u2265\u20092\u2009years in Europe) who remains symptomatic despite antihistamine therapy. Additional adult indications include prurigo nodularis, bullous pemphigoid, and chronic obstructive pulmonary disease with an eosinophilic phenotype. Beyond these established indications, increasing evidence suggests a broader therapeutic potential for dupilumab in paediatric diseases characterized by T2 immune dysregulation. This narrative review synthesizes the emerging literature on off\u2010label and investigational paediatric uses of dupilumab, focusing on inflammatory skin diseases, inborn errors of immunity with severe atopic phenotypes, transplant\u2010associated immune dysregulation, selected respiratory conditions and food allergy. Although current evidence largely derives from case reports, small case series, and observational studies, reported outcomes consistently indicate significant improvements in disease severity, and quality of life, with a favourable safety profile. These findings highlight the expanding role of IL\u20104\/IL\u201013 blockade in paediatrics and underscore the need for prospective studies to better define efficacy, long\u2010term safety, and optimal patient selection in emerging indications.<\/jats:p>","DOI":"10.1111\/cea.70381","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:21:06Z","timestamp":1782271266000},"page":"1162-1176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging Paediatric Uses of Dupilumab Beyond Approvals"],"prefix":"10.1111","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-5605","authenticated-orcid":false,"given":"Simone","family":"Foti Randazzese","sequence":"first","affiliation":[{"name":"Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences University of Pavia  Pavia Italy"},{"name":"Pediatric Clinic Fondazione IRCCS Policlinico San Matteo  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