{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T23:45:50Z","timestamp":1791762350480,"version":"4.3.4"},"reference-count":9,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1241933"],"award-info":[{"award-number":["1241933"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin Experimental Allergy"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:list list-type=\"bullet\">\n                      <jats:list-item>\n                        <jats:p>PROTEGO is a Chilean cluster\u2010randomised crossover trial of vernix caseosa retention to prevent atopic dermatitis.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>1383 mother\u2010infant dyads will be enrolled and followed for atopic dermatitis until 12\u2009months.<\/jats:p>\n                      <\/jats:list-item>\n                    <\/jats:list>\n                  <\/jats:p>","DOI":"10.1111\/cea.70449","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T23:44:51Z","timestamp":1791762291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>PROTEGO<\/scp>\n                    Study Protocol: A Cluster Randomised Crossover Trial of Vernix Caseosa Retention for Primary Prevention of Atopic Dermatitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7904-262X","authenticated-orcid":false,"given":"Arturo","family":"Borzutzky","sequence":"first","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-3966","authenticated-orcid":false,"given":"Carolina","family":"Cabal\u00edn","sequence":"additional","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-7899","authenticated-orcid":false,"given":"Juan Pablo","family":"Fraga","sequence":"additional","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Fabres","sequence":"additional","affiliation":[{"name":"Department of Neonatology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-2567","authenticated-orcid":false,"given":"Alberto","family":"Toso","sequence":"additional","affiliation":[{"name":"Department of Neonatology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0473-2295","authenticated-orcid":false,"given":"Marcelo","family":"Far\u00edas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0202-3954","authenticated-orcid":false,"given":"Mar\u00eda Laura","family":"Cossio","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Dermatology Division, Department of Pediatrics University of Montreal  Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Escalante","sequence":"additional","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Fajuri","sequence":"additional","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2677-815X","authenticated-orcid":false,"given":"Maite","family":"Rojas\u2010Mckenzie","sequence":"additional","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Sande","sequence":"additional","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-5917","authenticated-orcid":false,"given":"Rosario","family":"Willatt","sequence":"additional","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Barrientos","sequence":"additional","affiliation":[{"name":"Translational Allergy and Immunology Laboratory, Department of Pediatric Infectious Diseases and Immunology School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-7580","authenticated-orcid":false,"given":"Robert J.","family":"Boyle","sequence":"additional","affiliation":[{"name":"Mohn Centre for Children's Health and Wellbeing, School of Public Health, Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_1_10_2_1","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1056\/NEJMra074081","article-title":"Atopic Dermatitis","volume":"358","author":"Bieber T.","year":"2008","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_1_10_3_1","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1097\/DER.0000000000000904","article-title":"Atopic Dermatitis in Latin America: A Roadmap to Address Data Collection, Knowledge Gaps, and Challenges","volume":"33","author":"Borzutzky A.","year":"2022","journal-title":"Dermatitis"},{"key":"e_1_2_1_10_4_1","first-page":"925","article-title":"The Natural Course of Atopic Dermatitis From Birth to Age 7\u2009Years and the Association With Asthma","volume":"113","author":"Illi S.","year":"2004","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"e_1_2_1_10_5_1","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0140-6736(19)32984-8","article-title":"Daily Emollient During Infancy for Prevention of Eczema: The BEEP Randomised Controlled Trial","volume":"395","author":"Chalmers J. R.","year":"2020","journal-title":"Lancet"},{"key":"e_1_2_1_10_6_1","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1007\/s00018-005-5260-7","article-title":"Vernix Caseosa as a Multi\u2010Component Defence System Based on Polypeptides, Lipids and Their Interactions","volume":"62","author":"Tollin M.","year":"2005","journal-title":"Cellular and Molecular Life Sciences"},{"key":"e_1_2_1_10_7_1","unstructured":"C.Cabal\u00edn M.Dibarrat I.Vera et\u00a0al. \u201cPhysicochemical Antimicrobial and Anti\u2010Inflammatory Properties of Vernix Caseosa for Its Application as a Topical Treatment for Atopic Dermatitis \u201dEAACI\u2010ESCD Skin Allergy Meeting; 2023 Mar 24\u201325."},{"key":"e_1_2_1_10_8_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/sj.jp.7211305","article-title":"Vernix Caseosa in Neonatal Adaptation","volume":"25","author":"Visscher M. O.","year":"2005","journal-title":"Journal of Perinatology"},{"key":"e_1_2_1_10_9_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.64252\/tc1vd872","article-title":"Vernix Caseosa: Benefits and Clinical Implications in Neonatal Care; A Study Conducted at Almak Nimr University Hospital, Shendi, Sudan","volume":"11","author":"Ahmed S. O. M.","year":"2025","journal-title":"International Journal of Environmental Sciences"},{"key":"e_1_2_1_10_10_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/bjd.19831","article-title":"Diagnosing Atopic Dermatitis in Infancy Using Established Diagnostic Criteria: A Cohort Study","volume":"186","author":"Endre K. M. A.","year":"2022","journal-title":"British Journal of Dermatology"}],"container-title":["Clinical &amp; Experimental Allergy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.70449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cea.70449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cea.70449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T23:44:53Z","timestamp":1791762293000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cea.70449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,11]]},"references-count":9,"alternative-id":["10.1111\/cea.70449"],"URL":"https:\/\/doi.org\/10.1111\/cea.70449","archive":["Portico"],"relation":{},"ISSN":["0954-7894","1365-2222"],"issn-type":[{"value":"0954-7894","type":"print"},{"value":"1365-2222","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,11]]},"assertion":[{"value":"2026-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cea.70449"}}