{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:59:17Z","timestamp":1780451957844,"version":"3.54.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":931,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1111\/ced.12018","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T11:34:48Z","timestamp":1360668888000},"page":"185-188","source":"Crossref","is-referenced-by-count":55,"title":["Nicotinamide downregulates gene expression of interleukin-6, interleukin-10, monocyte chemoattractant protein-1, and tumour necrosis factor-\u03b1 gene expression in HaCaT keratinocytes after ultraviolet B irradiation"],"prefix":"10.1093","volume":"38","author":[{"given":"G.","family":"Monfrecola","sequence":"first","affiliation":[{"name":"Department of Dermatology; University of Naples Federico II; Naples; Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gaudiello","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of Naples Federico II; Naples; Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of Naples Federico II; Naples; Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fabbrocini","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of Naples Federico II; Naples; Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Balato","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of Naples Federico II; Naples; Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lembo","sequence":"additional","affiliation":[{"name":"Department of Dermatology; University of Naples Federico II; Naples; Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,2,12]]},"reference":[{"key":"10.1111\/ced.12018-BIB0001|ced12018-cit-0001","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1124\/pr.54.3.375","article-title":"The therapeutic potential of poly (ADP-ribose) polymerase inhibitors","volume":"54","author":"Vir\u00e1g","year":"2002","journal-title":"Pharmacol Rev"},{"key":"10.1111\/ced.12018-BIB0002|ced12018-cit-0002","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/j.1751-1097.2010.00746.x","article-title":"Nicotinamide prevents ultraviolet radiation-induced cellular energy loss","volume":"86","author":"Joohong","year":"2010","journal-title":"Photochem Photobiol"},{"key":"10.1111\/ced.12018-BIB0003|ced12018-cit-0003","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.1365-2249.2003.02031.x","article-title":"Nicotinamide is a potent inhibitor of proinflammatory cytokines","volume":"131","author":"Ungerstedt","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/ced.12018-BIB0004|ced12018-cit-0004","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jdermsci.2009.08.001","article-title":"Nicotinamide inhibits Propionibacterium acnes-induced IL-8 production in keratinocytes through the NF-kB and MAPK pathways","volume":"56","author":"Grange","year":"2009","journal-title":"J Dermatol Sci"},{"key":"10.1111\/ced.12018-BIB0005|ced12018-cit-0005","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/sj.jid.5701058","article-title":"Ultraviolet radiation induced immunosuppression is greater in men and prevented by topical nicotinamide","volume":"128","author":"Damian","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1111\/ced.12018-BIB0006|ced12018-cit-0006","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1365-2133.2009.09244.x","article-title":"Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans","volume":"161","author":"Sivapirabu","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1111\/ced.12018-BIB0007|ced12018-cit-0007","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.cellbi.2008.08.011","article-title":"Release of cytokines\/chemokines and cell death in UVB-irradiated human keratinocytes, HaCaT","volume":"32","author":"Yoshizumi","year":"2008","journal-title":"Cell Biol Int"},{"key":"10.1111\/ced.12018-BIB0008|ced12018-cit-0008","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0923-1811(03)00039-2","article-title":"Downregulation of NF-kB activation in human keratinocytes by melanogenic inhibitors","volume":"31","author":"Ahn","year":"2003","journal-title":"J Dermatol Sci"},{"key":"10.1111\/ced.12018-BIB0009|ced12018-cit-0009","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.tips.2011.08.002","article-title":"Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials","volume":"32","author":"Lukasova","year":"2011","journal-title":"Trends Pharmacol Sci"},{"key":"10.1111\/ced.12018-BIB0010|ced12018-cit-0010","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/jid.2011.459","article-title":"Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials","volume":"132","author":"Surjana","year":"2012","journal-title":"J Invest Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fced.12018","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ced.12018\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:37:35Z","timestamp":1676385455000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/38\/2\/185\/6622878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,12]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"URL":"https:\/\/doi.org\/10.1111\/ced.12018","relation":{},"ISSN":["0307-6938"],"issn-type":[{"value":"0307-6938","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2,12]]}}}