{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:17:11Z","timestamp":1788891431229,"version":"build-2803163510"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Background<\/jats:p><jats:p>Regulatory T cells (Tregs), together with tolerogenic dendritic cells (tDCs) are involved in maintaining peripheral tolerance. A recent report suggested both Tregs and tDCs may be pathogenic in granulomatous skin disorders.<\/jats:p><jats:p>Aim<\/jats:p><jats:p>To examined the expression of CD39 on granuloma-composing cells and Foxp3-positive Tregs in the skin in two representative granulomatous diseases, sarcoidosis and granuloma annulare (GA).<\/jats:p><jats:p>Methods<\/jats:p><jats:p>We immunohistologically examined expression of CD39 on granuloma-composing cells and expression of Foxp3 on CD4+ or CD25+ cells in fixed sections of lesional skin from 16 patients with sarcoidosis and five patients with GA.<\/jats:p><jats:p>Results<\/jats:p><jats:p>The granuloma-composing cells expressed CD39 in both sarcoidosis and GA. Significant numbers of CD4+ Foxp3+ Tregs were present diffusely throughout the granulomatous tissues in sarcoidosis, whereas Tregs in GA existed only at the peripheral lesion of palisading granulomatous tissue.<\/jats:p><jats:p>Conclusions<\/jats:p><jats:p>There was infiltration of increased numbers of Foxp3+ Tregs around the CD39+ granuloma-composing cells in both GA and sarcoidosis.<\/jats:p>","DOI":"10.1111\/ced.12094","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T06:48:04Z","timestamp":1384930084000},"page":"883-889","source":"Crossref","is-referenced-by-count":7,"title":["Expression of CD39\/Entpd1 on granuloma-composing cells and induction of Foxp3-positive regulatory T cells in sarcoidosis"],"prefix":"10.1093","volume":"38","author":[{"given":"T.","family":"Fujimura","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai 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