{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:38Z","timestamp":1787013998140,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Background<\/jats:p>\n                  <jats:p>The Kv1.3 voltage-gated potassium channel is selectively upregulated upon activation in effector memory T (TEM) cells in inflamed tissue, and plays an important role in maintenance of T-cell activation. Although Kv1.3 blockers have been shown to ameliorate allergic contact dermatitis (ACD) in a rat model, it remains unknown whether the effect of Kv1.3 blockers on ACD is mediated by suppressing TEM cell function and\/or whether naive T-cells or central memory T (TCM) cells are influenced.<\/jats:p>\n                  <jats:p>Aim<\/jats:p>\n                  <jats:p>To analyse the detailed mechanism of Kv1.3 blockers in a rat model of ACD.<\/jats:p>\n                  <jats:p>Methods<\/jats:p>\n                  <jats:p>We examined the effects of a Kv1.3 blocker on inflammation and production of the effector cytokine interferon (IFN)-\u03b3 in inflamed tissue in rat ACD. Single-cell suspensions were isolated from inflamed rat ears (TEM cells), and regional lymph nodes (naive T\/TCM cells), and the effect of Kv1.3 blockers on anti-CD3-stimulated IFN-\u03b3 production in vitro was measured.<\/jats:p>\n                  <jats:p>Results<\/jats:p>\n                  <jats:p>The Kv1.3 blocker significantly suppressed ear inflammation and IFN-\u03b3 production at the protein level in vivo. It also suppressed in vitro IFN-\u03b3 production from TEM cells from inflamed tissues, but did not suppress the function of naive T\/TCM cells from lymph nodes.<\/jats:p>\n                  <jats:p>Conclusions<\/jats:p>\n                  <jats:p>We found that the Kv1.3 blocker ameliorated ACD by inhibiting TEM cell functions only, thus Kv1.3 blockers could be a potentially selective therapeutic agent for TEM cell-mediated inflammatory skin diseases without producing harmful side-effects.<\/jats:p>","DOI":"10.1111\/ced.12097","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T01:48:04Z","timestamp":1384912084000},"page":"897-903","source":"Crossref","is-referenced-by-count":10,"title":["Kv1.3 blockers ameliorate allergic contact dermatitis by preferentially suppressing effector memory T cells in a rat model"],"prefix":"10.1093","volume":"38","author":[{"given":"A.","family":"Ueyama","sequence":"first","affiliation":[{"name":"Innovative Drug Discovery Research Laboratories Shionogi and Co. Ltd Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Imura","sequence":"additional","affiliation":[{"name":"Medicinal Research Laboratories Shionogi and Co. Ltd Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Kasai-Yamamoto","sequence":"additional","affiliation":[{"name":"Medicinal Research Laboratories Shionogi and Co. Ltd Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Tai","sequence":"additional","affiliation":[{"name":"Medicinal Research Laboratories Shionogi and Co. Ltd Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nagira","sequence":"additional","affiliation":[{"name":"Medicinal Research Laboratories Shionogi and Co. Ltd Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Shichijo","sequence":"additional","affiliation":[{"name":"Medicinal Research Laboratories Shionogi and Co. Ltd Toyonaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yasui","sequence":"additional","affiliation":[{"name":"Medicinal Research Laboratories Shionogi and Co. 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