{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:15:32Z","timestamp":1791220532691,"version":"4.1.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>\u03b2-catenin plays an important role in hair morphogenesis. Previously, the nuclear and cytoplasmic localizations of \u03b2-catenin were identified in hair-matrix cells. To evaluate \u03b2-catenin expression in the nail matrix, we obtained human nail units. Immunohistochemistry for \u03b2-catenin was used to evaluate sections of normal nail units and of sections from a single case of onychomatricoma. In the nail unit, \u03b2-catenin was expressed in the nucleus and cytoplasm of the suprabasal nail-matrix cells. Of the other epithelial-cell types, only the cell membrane was \u03b2-catenin-positive. In the nail tissue from the onychomatricoma case, \u03b2-catenin was expressed in the nucleus and cytoplasm of the upper epithelial layers. Our result suggests that \u03b2-catenin plays an important role in nail formation. In addition, \u03b2-catenin expression in onychomatricoma supports the presence of nail-matrix cells in this condition. To our knowledge, this is the first report of \u03b2-catenin expression in the nucleus and cytoplasm of the nail matrix.<\/jats:p>","DOI":"10.1111\/ced.12139","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T06:48:04Z","timestamp":1384930084000},"page":"917-920","source":"Crossref","is-referenced-by-count":11,"title":["Nuclear and cytoplasmic localization of \u03b2-catenin in the nail-matrix cells and in an onychomatricoma"],"prefix":"10.1093","volume":"38","author":[{"given":"C.-R.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of DermatologySamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-T.","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of DermatologySamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of DermatologySamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.-Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of DermatologySamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-M.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of DermatologySamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Y.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of PathologySamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.-T.","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of PathologySamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.-H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of AnatomySamsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,12,1]]},"reference":[{"key":"2023012703534358900_ced12139-bib-0001","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1467-2494.2007.00372.x","article-title":"Nail biology and nail science","volume":"29","author":"De Berker","year":"2007","journal-title":"Int J Cosmet Sci"},{"key":"2023012703534358900_ced12139-bib-0002","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2559.2012.04210.x","article-title":"The presence and localization of onychodermis (specialized nail mesenchyme) containing onychofibroblasts in the nail unit: a morphologic and immunohistochemical study","volume":"61","author":"Lee","year":"2012","journal-title":"Histopathology"},{"key":"2023012703534358900_ced12139-bib-0003","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1540-9740.2005.02366.x","article-title":"Hair and nail relationship","volume":"4","author":"Baran","year":"2005","journal-title":"Skinmed"},{"key":"2023012703534358900_ced12139-bib-0004","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1365-2133.2004.06108.x","article-title":"Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed","volume":"151","author":"Perrin","year":"2004","journal-title":"Br J Dermatol"},{"key":"2023012703534358900_ced12139-bib-0005","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1365-2230.2011.04324.x","article-title":"Immunohistochemical study of epithelial markers in longitudinal and transverse sections of the human nail unit","volume":"37","author":"Lee","year":"2012","journal-title":"Clin Exp Dermatol"},{"key":"2023012703534358900_ced12139-bib-0006","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","article-title":"Beta-catenin controls hair follicle morphogenesis and stem cell differentiation in the skin","volume":"105","author":"Huelsken","year":"2001","journal-title":"Cell"},{"key":"2023012703534358900_ced12139-bib-0007","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1046\/j.1365-2133.2001.04455.x","article-title":"Beta-catenin expression in pilomatrixomas. 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