{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:23:53Z","timestamp":1757312633539,"version":"3.37.3"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"},{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Dermatol"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1111\/ced.13008","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:16:41Z","timestamp":1483575401000},"page":"172-177","source":"Crossref","is-referenced-by-count":9,"title":["Toll-like receptor (TLR)7 expression in mycosis fungoides and psoriasis: a case-control study"],"prefix":"10.1093","volume":"42","author":[{"given":"A. M.","family":"El Tawdy","sequence":"first","affiliation":[{"name":"Dermatology Department; Faculty of Medicine; Cairo University; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. M.","family":"Amin","sequence":"additional","affiliation":[{"name":"Dermatology Department; Faculty of Medicine; Cairo University; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-0796","authenticated-orcid":false,"given":"R. M.","family":"Abdel Hay","sequence":"additional","affiliation":[{"name":"Dermatology Department; Faculty of Medicine; Cairo University; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Dermatology Department; Faculty of Medicine; Cairo University; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. S.","family":"Gad","sequence":"additional","affiliation":[{"name":"Surgical Oncology Department; National Cancer Institute; Cairo University; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A.","family":"Rashed","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Department; Faculty of Medicine; Cairo University; Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"10.1111\/ced.13008-BIB0001|ced13008-cit-0001","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)80172-5","article-title":"The dorsoventral regulatory gene cassette sp\u00e4tzle\/Toll\/cactus controls the potent antifungal response in Drosophila adults","volume":"86","author":"Lemaitre","year":"1996","journal-title":"Cell"},{"key":"10.1111\/ced.13008-BIB0002|ced13008-cit-0002","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1365-4632.2009.04111.x","article-title":"Toll-like receptors and dermatology","volume":"48","author":"Petry","year":"2009","journal-title":"Int J Dermatol"},{"key":"10.1111\/ced.13008-BIB0003|ced13008-cit-0003","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1001\/archderm.138.9.1137","article-title":"Treatment of stage IA cutaneous T-cell lymphoma with topical.application of the immune response modifier imiquimod","volume":"138","author":"Suchin","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1111\/ced.13008-BIB0004|ced13008-cit-0004","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3109\/10428194.2011.582202","article-title":"Synergistic enhancement of cellular immune responses by the novel Toll receptor 7\/8 agonist 3M 007 and interferon-\u03b3: implications for therapy of cutaneous T-cell lymphoma","volume":"52","author":"Wysocka","year":"2011","journal-title":"Leuk Lymphoma"},{"key":"10.1111\/ced.13008-BIB0005|ced13008-cit-0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0002-9440(10)61675-6","article-title":"HLA-G and NK receptor are expressed in psoriatic skin: a possible pathway for regulating infiltrating T cells","volume":"159","author":"Aractingi","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1111\/ced.13008-BIB0006|ced13008-cit-0006","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/labinvest.3780242","article-title":"Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris","volume":"81","author":"Rottman","year":"2001","journal-title":"Lab Invest"},{"key":"10.1111\/ced.13008-BIB0007|ced13008-cit-0007","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1001\/archderm.140.12.1490","article-title":"Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors","volume":"140","author":"Gilliet","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1111\/ced.13008-BIB0008|ced13008-cit-0008","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1084\/jem.194.6.863","article-title":"Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens","volume":"194","author":"Kadowaki","year":"2001","journal-title":"J Exp Med"},{"key":"10.1111\/ced.13008-BIB0009|ced13008-cit-0009","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1182\/blood-2007-03-055749","article-title":"Revisions to the staging and classification of mycosis fungoides and S\u00e9zary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)","volume":"110","author":"Olsen","year":"2007","journal-title":"Blood"},{"key":"10.1111\/ced.13008-BIB0010|ced13008-cit-0010","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1365-2133.2005.06502.x","article-title":"Current severe psoriasis and the role of TENS","volume":"152","author":"Finlay","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1111\/ced.13008-BIB0011|ced13008-cit-0011","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1111\/ced.13008-BIB0012|ced13008-cit-0012","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/CCO.0000000000000048","article-title":"Toll receptor agonist therapy of skin cancer and cutaneous T-cell lymphoma","volume":"26","author":"Huen","year":"2014","journal-title":"Curr Opin Oncol"},{"key":"10.1111\/ced.13008-BIB0013|ced13008-cit-0013","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.0303-6987.2005.00297.x","article-title":"Enhanced type I interferon signaling and recruitment of chemokine receptor CXCR3-expressing lymphocytes into the skin following treatment with the TLR7-agonist imiquimod","volume":"32","author":"Wenzel","year":"2005","journal-title":"J Cutan Pathol"},{"key":"10.1111\/ced.13008-BIB0014|ced13008-cit-0014","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1006\/cyto.1997.0239","article-title":"Induction of cytokines in cynomolgus monkeys by the immune response modifiers, imiquimod, S-27609 and S-28463","volume":"9","author":"Wagner","year":"1997","journal-title":"Cytokine"},{"key":"10.1111\/ced.13008-BIB0015|ced13008-cit-0015","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/DAD.0b013e3182448f7c","article-title":"Mapping Toll-like receptor activity in different stages of cutaneous T-cell lymphoma","volume":"34","author":"Kado","year":"2012","journal-title":"Am J Dermatopathol"},{"key":"10.1111\/ced.13008-BIB0016|ced13008-cit-0016","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2217\/imt.09.70","article-title":"Toll-like receptor agonists in cancer therapy","volume":"1","author":"Adams","year":"2009","journal-title":"Immunotherapy"},{"key":"10.1111\/ced.13008-BIB0017|ced13008-cit-0017","doi-asserted-by":"crossref","first-page":"e77159","DOI":"10.1371\/journal.pone.0077159","article-title":"Roles of TLR7 in activation of NF-\u03baB signaling of keratinocytes by imiquimod","volume":"8","author":"Li","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1111\/ced.13008-BIB0018|ced13008-cit-0018","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/ni1141","article-title":"Plasmacytoid dendritic cells in immunity","volume":"5","author":"Colonna","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1111\/ced.13008-BIB0019|ced13008-cit-0019","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.4049\/jimmunol.170.10.5195","article-title":"Monocyte-derived dendritic cells generated after a short-term culture with IFN-alpha and granulocyte-macrophage colony-stimulating factor stimulate a potent Epstein-Barr virus-specific CD8 + T cell response","volume":"170","author":"Santodonato","year":"2003","journal-title":"J Immunol"},{"key":"10.1111\/ced.13008-BIB0020|ced13008-cit-0020","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.4049\/jimmunol.171.7.3385","article-title":"IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities","volume":"171","author":"Mohty","year":"2003","journal-title":"J Immunol"},{"key":"10.1111\/ced.13008-BIB0021|ced13008-cit-0021","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1111\/ced.13008-BIB0022|ced13008-cit-0022","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1046\/j.1523-1747.1998.00446.x","article-title":"Expression of interleukin-12 is increased in psoriatic skin","volume":"111","author":"Yawalkar","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1111\/ced.13008-BIB0023|ced13008-cit-0023","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.20041257","article-title":"IL-23 drives a pathogenic T cell population that induces autoimmune inflammation","volume":"201","author":"Langrish","year":"2005","journal-title":"J Exp Med"},{"key":"10.1111\/ced.13008-BIB0024|ced13008-cit-0024","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1084\/jem.20030451","article-title":"Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris","volume":"199","author":"Lee","year":"2004","journal-title":"J Exp Med"},{"key":"10.1111\/ced.13008-BIB0025|ced13008-cit-0025","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S1074-7613(02)00324-2","article-title":"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells","volume":"16","author":"Pflanz","year":"2002","journal-title":"Immunity"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fced.13008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ced.13008\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T09:43:48Z","timestamp":1676367828000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/42\/2\/172\/6621532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,5]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"URL":"https:\/\/doi.org\/10.1111\/ced.13008","archive":["Portico"],"relation":{},"ISSN":["0307-6938"],"issn-type":[{"type":"print","value":"0307-6938"}],"subject":[],"published":{"date-parts":[[2017,1,5]]}}}