{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:21:12Z","timestamp":1790680872728,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Gerencia Regional de Salud, Junta de Castilla y Le\u00f3n","award":["GRS 1342\/A\/16"],"award-info":[{"award-number":["GRS 1342\/A\/16"]}]},{"name":"Gerencia Regional de Salud, Junta de Castilla y Le\u00f3n","award":["INT\/M\/16\/17"],"award-info":[{"award-number":["INT\/M\/16\/17"]}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2014-56989-R"],"award-info":[{"award-number":["SAF2014-56989-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PIE14\/00066"],"award-info":[{"award-number":["PIE14\/00066"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"crossref","award":["BIO\/SA31\/15"],"award-info":[{"award-number":["BIO\/SA31\/15"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"crossref","award":["CSI001416"],"award-info":[{"award-number":["CSI001416"]}],"id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"crossref"}]},{"name":"IBSAL","award":["IBY15\/00003"],"award-info":[{"award-number":["IBY15\/00003"]}]},{"DOI":"10.13039\/100008055","name":"Fundaci\u00f3n Eugenio Rodr\u00edguez Pascual","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007649","name":"Fundaci\u00f3n Sandra Ibarra de Solidaridad Frente al C\u00e1ncer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007649","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Heroes Foundation","award":["Q3718001E"],"award-info":[{"award-number":["Q3718001E"]}]},{"name":"Heroes Foundation","award":["GRS 612\/A\/11"],"award-info":[{"award-number":["GRS 612\/A\/11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Exp Dermatol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1111\/ced.13570","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:40:34Z","timestamp":1526258434000},"page":"876-882","source":"Crossref","is-referenced-by-count":26,"title":["Rapid growth rate is associated with poor prognosis in cutaneous squamous cell carcinoma"],"prefix":"10.1093","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-7353","authenticated-orcid":false,"given":"J.","family":"Ca\u00f1ueto","sequence":"first","affiliation":[{"name":"Department of Dermatology; Hospital Universitario de Salamanca; Paseo de San Vicente Salamanca Spain"},{"name":"Institute of Biomedical Medicine of Salamanca (IBSAL); Hospital Universitario de Salamanca; Paseo de San Vicente Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mart\u00edn-Vallejo","sequence":"additional","affiliation":[{"name":"Department of Statistics; Facultad de Medicina; Universidad de Salamanca; Campus Miguel de Unamuno Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Carde\u00f1oso-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Hospital Virgen de la Concha; Avenida de Requejo; Zamora Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fern\u00e1ndez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Hospital Universitario de Salamanca; Paseo de San Vicente Salamanca Spain"},{"name":"Institute of Biomedical Medicine of Salamanca (IBSAL); Hospital Universitario de Salamanca; Paseo de San Vicente Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"P\u00e9rez-Losada","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Medicine of Salamanca (IBSAL); Hospital Universitario de Salamanca; Paseo de San Vicente Salamanca Spain"},{"name":"Institute of Molecular and Cellular Cancer Biology (IBMCC); Centro de investigaci\u00f3n del C\u00e1ncer (CIC); Instituto Mixto Universidad de Salamanca\/CSIC; Campus Miguel de Unamuno Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Rom\u00e1n-Curto","sequence":"additional","affiliation":[{"name":"Department of Dermatology; Hospital Universitario de Salamanca; Paseo de San Vicente Salamanca Spain"},{"name":"Institute of Biomedical Medicine of Salamanca (IBSAL); Hospital Universitario de Salamanca; Paseo de San Vicente Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,5,13]]},"reference":[{"key":"10.1111\/ced.13570-BIB0001|ced13570-cit-0001","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1046\/j.0007-0963.2001.04615.x","article-title":"Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma","volume":"146","author":"Motley","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1111\/ced.13570-BIB0002|ced13570-cit-0002","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1056\/NEJM199212033272307","article-title":"Nonmelanoma cancers of the skin","volume":"327","author":"Preston","year":"1992","journal-title":"N Engl J Med"},{"key":"10.1111\/ced.13570-BIB0003|ced13570-cit-0003","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jaad.2012.11.037","article-title":"Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012","volume":"68","author":"Karia","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/ced.13570-BIB0004|ced13570-cit-0004","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0190-9622(08)81509-5","article-title":"Nonmelanoma skin cancer in the United States: incidence","volume":"30","author":"Miller","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/ced.13570-BIB0005|ced13570-cit-0005","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1470-2045(08)70178-5","article-title":"Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study","volume":"9","author":"Brantsch","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1111\/ced.13570-BIB0006|ced13570-cit-0006","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1001\/jamadermatol.2013.746","article-title":"Outcomes of primary cutaneous squamous cell carcinoma with perineural invasion: an 11-year cohort study","volume":"149","author":"Carter","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1111\/ced.13570-BIB0007|ced13570-cit-0007","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1200\/JCO.2012.48.5326","article-title":"Evaluation of American Joint Committee on Cancer, International Union Against Cancer, and Brigham and Women's Hospital tumor staging for cutaneous squamous cell carcinoma","volume":"32","author":"Karia","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1111\/ced.13570-BIB0008|ced13570-cit-0008","first-page":"4067","article-title":"Clinical estimation of the growth rate of lung cancer","volume":"21","author":"Mattern","year":"2001","journal-title":"Anticancer Res"},{"key":"10.1111\/ced.13570-BIB0009|ced13570-cit-0009","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1097\/01.ju.0000136315.80057.99","article-title":"Natural history of small renal cell carcinoma: evaluation of growth rate, histological grade, cell proliferation and apoptosis","volume":"172","author":"Kato","year":"2004","journal-title":"J Urol"},{"key":"10.1111\/ced.13570-BIB0010|ced13570-cit-0010","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/bjc.1986.247","article-title":"Growth rate of primary breast cancer and prognosis: observations on a 3- to 7-year follow-up in 180 breast cancers","volume":"54","author":"Galante","year":"1986","journal-title":"Br J Cancer"},{"key":"10.1111\/ced.13570-BIB0011|ced13570-cit-0011","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.radonc.2014.06.004","article-title":"The importance of actual tumor growth rate on disease free survival and overall survival in laryngeal squamous cell carcinoma","volume":"112","author":"van Bockel","journal-title":"Radiother Oncol"},{"key":"10.1111\/ced.13570-BIB0012|ced13570-cit-0012","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/bjc.1992.307","article-title":"Tumour growth rate and DNA flow cytometry parameters as prognostic factors in metastatic melanoma","volume":"66","author":"Muhonen","year":"1992","journal-title":"Br J Cancer"},{"key":"10.1111\/ced.13570-BIB0013|ced13570-cit-0013","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/archdermatol.2011.2522","article-title":"Prediction of sentinel lymph node positivity by growth rate of cutaneous melanoma","volume":"148","author":"Tejera-Vaquerizo","year":"2012","journal-title":"Arch Dermatol"},{"key":"10.1111\/ced.13570-BIB0014|ced13570-cit-0014","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1158\/1078-0432.CCR-13-2098","article-title":"Tumor growth rate is an early indicator of antitumor drug activity in phase I clinical trials","volume":"20","author":"Ferte","journal-title":"Clin Cancer Res"},{"key":"10.1111\/ced.13570-BIB0015|ced13570-cit-0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijrobp.2014.01.038","article-title":"Pretreatment growth rate predicts radiation response in vestibular schwannomas","volume":"89","author":"Niu","year":"2014","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1111\/ced.13570-BIB0016|ced13570-cit-0016","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1468-3083.2010.03723.x","article-title":"Correlation of the growth rate of melanoma with the temporal appearance of metastasis","volume":"25","author":"Tejera-Vaquerizo","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1111\/ced.13570-BIB0017|ced13570-cit-0017","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/jid.2011.433","article-title":"Chronology of metastasis in cutaneous melanoma: growth rate model","volume":"132","author":"Tejera-Vaquerizo","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1111\/ced.13570-BIB0018|ced13570-cit-0018","unstructured":"Oncology NNCCNCPi Squamous cell skin cancer https:\/\/www.nccn.org\/professionals\/physician_gls\/default.aspx"},{"key":"10.1111\/ced.13570-BIB0019|ced13570-cit-0019","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/00000421-198512000-00004","article-title":"Acute epithelioma-an aggressive squamous cell carcinoma of the skin","volume":"8","author":"Fitzpatrick","year":"1985","journal-title":"Am J Clin Oncol"},{"key":"10.1111\/ced.13570-BIB0020|ced13570-cit-0020","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.ejca.2015.06.110","article-title":"Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline","volume":"51","author":"Stratigos","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1111\/ced.13570-BIB0021|ced13570-cit-0021","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jaad.2013.11.009","article-title":"Basal cell carcinoma and squamous cell carcinoma growth rates and determinants of size in community patients","volume":"70","author":"Kricker","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/ced.13570-BIB0022|ced13570-cit-0022","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/0190-9622(92)70074-P","article-title":"Squamous cell carcinoma of the skin (excluding lip and oral mucosa)","volume":"26","author":"Johnson","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/ced.13570-BIB0023|ced13570-cit-0023","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jaad.2012.01.010","article-title":"The 7th edition AJCC staging system for cutaneous squamous cell carcinoma accurately predicts risk of recurrence for heart and lung transplant recipients","volume":"67","author":"Metchnikoff","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/ced.13570-BIB0024|ced13570-cit-0024","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/j.0022-202X.2004.23546.x","article-title":"Relationship of treatment delay with surgical defect size from keratinocyte carcinoma (basal cell carcinoma and squamous cell carcinoma of the skin)","volume":"124","author":"Eide","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1111\/ced.13570-BIB0025|ced13570-cit-0025","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jaad.2009.09.044","article-title":"Factors associated with large cutaneous squamous cell carcinomas","volume":"63","author":"Renzi","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1111\/ced.13570-BIB0026|ced13570-cit-0026","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/archderm.144.4.555","article-title":"Correlation of subjective self-reported melanoma growth rate with objective tumor proliferation markers","volume":"144","author":"Liu","year":"2008","journal-title":"Arch Dermatol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fced.13570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/ced.13570\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T09:46:31Z","timestamp":1676367991000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/43\/8\/876\/6597613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,13]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1111\/ced.13570","archive":["Portico"],"relation":{},"ISSN":["0307-6938"],"issn-type":[{"value":"0307-6938","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5,13]]}}}