{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:35:53Z","timestamp":1778272553363,"version":"3.51.4"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Calciphylaxis is a life-threatening cutaneous ulcerative\/necrotic disease characterized by vascular calcification\/occlusion. It occurs most commonly in end-stage kidney disease (ESKD), known as uraemic calciphylaxis (UC) but can also occur in patients with chronic kidney disease (CKD) and normal kidney function (nonuraemic calciphylaxis; NUC). There are few large series of NUC in the literature.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To compare the clinicopathological features of UC and NUC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively compared the clinicopathological features of 35 patients with NUC during the period 2010\u20132020 with those of 53 patients with UC (control group). Cases were classified as NUC in the absence of all of the following: ESKD, significant CKD (defined as serum creatinine &amp;gt; 3 mg\/dL or creatinine clearance &amp;lt; 15 mL\/min) and acute kidney injury requiring kidney replacement therapy or kidney transplantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>NUC represented 40% of the total cases, and there was a higher number of women (P &amp;lt; 0.01) and a higher median body mass index (P = 0.06) compared with the control UC group. Elevated parathyroid hormone was present in 44% of patients with NUC. Most of the tested patients were positive for lupus anticoagulants (56%). NUC biopsies showed a higher rate of extravascular calcium deposits (73% vs. 47%, P = 0.03). Dermal reactive vascular proliferation was the most common dermal change (32%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>NUC is more common than previously reported and shows a higher predilection for obese postmenopausal women. Undiagnosed hyperparathyroidism shows a possible association with NUC. Lupus anticoagulants were positive in most patients. NUC biopsies are more likely than UC biopsies to display extravascular calcium deposition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/ced.15009","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T17:14:20Z","timestamp":1636650860000},"page":"700-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Calciphylaxis in uraemic and nonuraemic settings: clinical risk factors and histopathological findings"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-1409","authenticated-orcid":false,"given":"E. I.","family":"Ababneh","sequence":"first","affiliation":[{"name":"Department of Pathology Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hassanein","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Cleveland Clinic Cleveland OH USA"},{"name":"Department of Cardiovascular Medicine Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Saad","sequence":"additional","affiliation":[{"name":"Department ofDermatology Cleveland Clinic Cleveland OH USA"},{"name":"Department of Nephrology and Hypertension University of Mississippi Medical Center Mississippi MO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. E.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0629-775X","authenticated-orcid":false,"given":"J. S.","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Fatica","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Vachharajani","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-8427","authenticated-orcid":false,"given":"A. P.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Pathology Detroit Medical Center Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2278-5908","authenticated-orcid":false,"given":"S. D.","family":"Billings","sequence":"additional","affiliation":[{"name":"Department of Pathology Cleveland Clinic Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,1]]},"reference":[{"key":"2023012704194465600_ced15009-bib-0001","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1056\/NEJMra1505292","article-title":"Calciphylaxis","volume":"378","author":"Nigwekar","year":"2018","journal-title":"N Engl J Med"},{"key":"2023012704194465600_ced15009-bib-0002","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/DAD.0b013e31827c7f5d","article-title":"Cutaneous calciphylaxis: a retrospective histopathologic evaluation","volume":"35","author":"Mochel","year":"2013","journal-title":"Am J Dermatopathol"},{"key":"2023012704194465600_ced15009-bib-0003","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/DAD.0000000000000824","article-title":"Histopathology of calciphylaxis: cohort study with clinical correlations","volume":"39","author":"Chen","year":"2017","journal-title":"Am J Dermatopathol"},{"key":"2023012704194465600_ced15009-bib-0004","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/PAS.0000000000001302","article-title":"Clinicopathologic features and calcium deposition patterns in calciphylaxis: comparison with gangrene, peripheral artery disease, chronic stasis, and thrombotic vasculopathy","volume":"43","author":"McMullen","year":"2019","journal-title":"Am J Surg Pathol"},{"key":"2023012704194465600_ced15009-bib-0005","first-page":"126","article-title":"Calcific uraemic arteriolopathy (calciphylaxis): data from a large nationwide registry","volume":"32","author":"Brandenburg","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"2023012704194465600_ced15009-bib-0006","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.mayocp.2016.06.025","article-title":"Survival, risk factors, and effect of treatment in 101 patients with calciphylaxis","volume":"91","author":"McCarthy","year":"2016","journal-title":"Mayo Clin Proc"},{"key":"2023012704194465600_ced15009-bib-0007","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2215\/CJN.00530108","article-title":"Calciphylaxis from nonuremic causes: a systematic review","volume":"3","author":"Nigwekar","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"2023012704194465600_ced15009-bib-0008","first-page":"24","article-title":"Calciphylaxis in patients with preserved kidney function","volume":"6","author":"Maroz","year":"2014","journal-title":"J Am Coll Clin Wound Spec"},{"key":"2023012704194465600_ced15009-bib-0009","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1001\/jamadermatol.2018.4937","article-title":"Demographics, comorbid conditions, and outcomes of patients with nonuremic calciphylaxis","volume":"155","author":"Altman","year":"2019","journal-title":"JAMA Dermatol"},{"key":"2023012704194465600_ced15009-bib-0010","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/jamadermatol.2016.4821","article-title":"Warfarin-associated nonuremic calciphylaxis","volume":"153","author":"Yu","year":"2017","journal-title":"JAMA Dermatol"},{"key":"2023012704194465600_ced15009-bib-0011","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1111\/jth.15047","article-title":"Guidance from the Scientific and Standardization Committee for lupus anticoagulant\/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis: update of the guidelines for lupus anticoagulant detection and interpretation","volume":"18","author":"Devreese","year":"2020","journal-title":"J Thromb Haemost"},{"key":"2023012704194465600_ced15009-bib-0012","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2042-6410-3-13","article-title":"Sex differences in human adipose tissues \u2013 the biology of pear shape","volume":"3","author":"Karastergiou","year":"2012","journal-title":"Biol Sex Differ"},{"key":"2023012704194465600_ced15009-bib-0013","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1210\/jcem.87.3.8354","article-title":"Estrogen status correlates with the calcium content of coronary atherosclerotic plaques in women","volume":"87","author":"Christian","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2023012704194465600_ced15009-bib-0014","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jaad.2007.12.006","article-title":"Pathogenesis of calciphylaxis: Hans Selye to nuclear factor \u03ba-B","volume":"58","author":"Weenig","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"2023012704194465600_ced15009-bib-0015","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1046\/j.1523-1755.2001.00803.x","article-title":"Risk factors and mortality associated with calciphylaxis in end-stage renal disease","volume":"60","author":"Mazhar","year":"2001","journal-title":"Kidney Int"},{"key":"2023012704194465600_ced15009-bib-0016","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0272-6386(00)70003-5","article-title":"Calcified subcutaneous arterioles with infarcts of the subcutis and skin (\u201ccalciphylaxis\u201d) in chronic renal failure","volume":"35","author":"Janigan","year":"2000","journal-title":"Am J Kidney Dis"},{"key":"2023012704194465600_ced15009-bib-0017","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/ndt\/gfz256","article-title":"The Australian Calciphylaxis Registry: reporting clinical features and outcomes of patients with calciphylaxis","volume":"36","author":"Ruderman","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"2023012704194465600_ced15009-bib-0018","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s40620-020-00908-9","article-title":"Calciphylaxis in end-stage kidney disease: outcome data from the United Kingdom Calciphylaxis Study","volume":"34","author":"Chinnadurai","year":"2021","journal-title":"J Nephrol"},{"key":"2023012704194465600_ced15009-bib-0019","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/GME.0000000000000989","article-title":"Is BMI a valid measure of obesity in postmenopausal women?","volume":"25","author":"Banack","year":"2018","journal-title":"Menopause"},{"key":"2023012704194465600_ced15009-bib-0020","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI24134","article-title":"Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia","volume":"115","author":"Nijenhuis","year":"2005","journal-title":"J Clin Invest"},{"key":"2023012704194465600_ced15009-bib-0021","doi-asserted-by":"crossref","first-page":"C869","DOI":"10.1152\/ajpcell.1994.267.4.C869","article-title":"The Na-K-Cl cotransporters","volume":"267","author":"Haas","year":"1994","journal-title":"Am J Physiol"},{"key":"2023012704194465600_ced15009-bib-0022","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.mayocp.2016.06.026","article-title":"Calciphylaxis: a disease of pannicular thrombosis","volume":"91","author":"el-Azhary","year":"2016","journal-title":"Mayo Clin Proc"},{"key":"2023012704194465600_ced15009-bib-0023","first-page":"47","article-title":"Anticoagulation proteins C and S","volume":"214","author":"Esmon","year":"1987","journal-title":"Adv Exp Med Biol"},{"key":"2023012704194465600_ced15009-bib-0024","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.kint.2018.03.016","article-title":"Questionable specificity of histologic findings in calcific uremic arteriolopathy","volume":"94","author":"Ellis","year":"2018","journal-title":"Kidney Int"},{"key":"2023012704194465600_ced15009-bib-0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/cup.13585","article-title":"Diffuse dermal angiomatosis associated with calciphylaxis: a 5-year retrospective institutional review","volume":"47","author":"O\u2019Connor","year":"2020","journal-title":"J Cutan Pathol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ced.15009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ced.15009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/47\/4\/700\/46941830\/ced0700.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/47\/4\/700\/46941830\/ced0700.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T04:43:02Z","timestamp":1674794582000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/47\/4\/700\/6693132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,1]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,1]]},"published-print":{"date-parts":[[2022,4,1]]}},"URL":"https:\/\/doi.org\/10.1111\/ced.15009","relation":{},"ISSN":["1365-2230","0307-6938"],"issn-type":[{"value":"1365-2230","type":"electronic"},{"value":"0307-6938","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2022,4,1]]},"assertion":[{"value":"2021-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}