{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T18:19:37Z","timestamp":1792433977094,"version":"4.5.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":162,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Nail disorders in general are difficult to treat and often frustrating, and this is also the case with nail psoriasis, especially when it is limited to the nails, and not affecting joints. The quality of life of patients with nail psoriasis is negatively affected, owing to the chronic course of the disease and frequent relapses. The purpose of this study was to compare treatment response and maintenance of response during follow-up of 12 patients with nail matrix psoriasis limited to a few nails, who were treated with intralesional injections of either methotrexate (MTX) 25\u2009mg\/mL or triamcinolone acetonide 10\u2009mg\/mL. Patients were treated every 6\u2009weeks for 24\u2009weeks and followed up for 6\u2009months. Photographic documentation and assessment by Nail Psoriasis Severity Index were performed during each treatment session and at each follow-up visit. At the end of the four treatment sessions, all patients had improvement of their disease, which continued during follow-up, especially for the MTX-treated group.<\/jats:p>","DOI":"10.1111\/ced.15110","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T07:29:11Z","timestamp":1643959751000},"page":"1165-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A pilot study of intralesional methotrexate injections versus triamcinolone acetonide in patients affected by nail matrix psoriasis"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3981-1527","authenticated-orcid":false,"given":"Michela","family":"Starace","sequence":"first","affiliation":[{"name":"Dermatology Unit, IRCCS Policlinico Sant'Orsola, Department of Experimental Diagnostic and Specialty Medicine (DIMES) Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-4861","authenticated-orcid":false,"given":"Aurora","family":"Alessandrini","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Policlinico Sant'Orsola, Department of Experimental Diagnostic and Specialty Medicine (DIMES) Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-5443","authenticated-orcid":false,"given":"Matilde","family":"Iorizzo","sequence":"additional","affiliation":[{"name":"Private Dermatology Practice Lugano and Bellinzona Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambra","family":"D'Altobrando","sequence":"additional","affiliation":[{"name":"Dermatology Unit, AUSL Romagna Ravenna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-0747","authenticated-orcid":false,"given":"Tiziano","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Policlinico Sant'Orsola, Department of Experimental Diagnostic and Specialty Medicine (DIMES) Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7248-425X","authenticated-orcid":false,"given":"Francesca","family":"Bruni","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Policlinico Sant'Orsola, Department of Experimental Diagnostic and Specialty Medicine (DIMES) Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Maria","family":"Piraccini","sequence":"additional","affiliation":[{"name":"Dermatology Unit, IRCCS Policlinico Sant'Orsola, Department of Experimental Diagnostic and Specialty Medicine (DIMES) Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jaad.2019.01.072","article-title":"Recommendations for the definition, evaluation, and treatment of nail psoriasis in adult patients with no or mild skin psoriasis: a dermatologist and nail expert group consensus","volume":"81","author":"Rigopoulos","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000323004","article-title":"Nail psoriasis successfully treated with intralesional methotrexate: case report","volume":"222","author":"Sar\u0131caoglu","year":"2011","journal-title":"Dermatology"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s13555-018-0261-2","article-title":"A case of nail psoriasis successfully treated with intralesional methotrexate","volume":"8","author":"Mokni","year":"2018","journal-title":"Dermatol Ther (Heidelb)"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4103\/ijdvl.IJDVL_73_16","article-title":"Intramatricial injections for nail psoriasis: an open-label comparative study of triamcinolone, methotrexate, and cyclosporine","volume":"4","author":"Mittal","year":"2018","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1590\/abd1806-4841.20198170","article-title":"Nail psoriasis treated with intralesional methotrexate infiltration","volume":"94","author":"Duarte","year":"2019","journal-title":"An Bras Dermatol"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.jaad.2020.04.159","article-title":"Treatment of nail psoriasis with intramatricial methotrexate: an uncontrolled prospective study of 20 patients","volume":"84","author":"Choudhary","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/ced.13087","article-title":"Role of nail bed methotrexate injections in isolated nail psoriasis: conventional drug via an unconventional route","volume":"42","author":"Grover","year":"2017","journal-title":"Clin Exp Dermatol"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1046\/j.1365-2133.1998.02031.x","article-title":"A simplified protocol of steroid injection for psoriatic nail dystrophy","volume":"138","author":"De Berker","year":"1998","journal-title":"Br J Dermatol"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.1038\/s41598-019-43899-9","article-title":"Th1, Th17, and Treg responses are differently modulated by TNF-\u03b1 inhibitors and methotrexate in psoriasis patients","volume":"9","author":"Furiati","year":"2019","journal-title":"Sci Rep"},{"key":"2023022412435056500_","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1468-3083.2010.03927.x","article-title":"Evaluation of the efficacy of methotrexate and cyclosporine therapies on psoriatic nails: a one-blind, randomized study","volume":"25","author":"Gumusel","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ced.15110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ced.15110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/47\/6\/1165\/49328425\/ced1165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/47\/6\/1165\/49328425\/ced1165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T22:55:34Z","timestamp":1700175334000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/47\/6\/1165\/6693120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":10,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6,1]]},"published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1111\/ced.15110","relation":{},"ISSN":["1365-2230","0307-6938"],"issn-type":[{"value":"1365-2230","type":"electronic"},{"value":"0307-6938","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,6,1]]},"assertion":[{"value":"2021-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}