{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:44:29Z","timestamp":1785361469829,"version":"3.55.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012295","name":"NIHR Newcastle Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012805","name":"Norwich University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012805","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>From the first report in 1969 to the present day, diagnosis of eccrine porocarcinoma, also known simply as porocarcinoma (PC), remains a challenge. This review presents a concise update of the history, pathogenesis, epidemiology, diagnosis, management and prognosis of this rare sweat gland neoplasm. PC differentiates towards the intraepidermal spiral ducts in the eccrine gland, is more common in people aged &amp;gt;\u200960\u2009years and often affects the head, neck and legs. PC presents as a dome-shaped papule, plaque or nodule growing over weeks to months. The exact incidence of PC is unknown but appears to be rising. Diagnosis is difficult because of variable presentations and similar clinical and histological features to cutaneous squamous cell carcinoma. Management involves removal of the tumour, usually using wide local excision or Mohs micrographic surgery. Prognosis is poor, with PC recurring after surgery in 35% of cases. Given the lack of standardized protocols and risk profiles, further studies would help improve the understanding of PC.<\/jats:p>","DOI":"10.1111\/ced.15126","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T07:53:12Z","timestamp":1644652392000},"page":"1030-1035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Porocarcinoma: a review"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-9631","authenticated-orcid":false,"given":"Jilse","family":"Joshy","sequence":"first","affiliation":[{"name":"Norwich Medical School University of East Anglia Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4770-9335","authenticated-orcid":false,"given":"Khaylen","family":"Mistry","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia Norwich UK"},{"name":"Department of Dermatology Norfolk and Norwich University Hospital Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-8305","authenticated-orcid":false,"given":"Nick J.","family":"Levell","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia Norwich UK"},{"name":"Department of Dermatology Norfolk and Norwich University Hospital Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-9017","authenticated-orcid":false,"given":"Birgitta","family":"Bodegraven","sequence":"additional","affiliation":[{"name":"British Association of Dermatologists London UK"},{"name":"National Disease Registration Service NHS Digital (NHSD) Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Vernon","sequence":"additional","affiliation":[{"name":"National Disease Registration Service NHS Digital (NHSD) Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-5680","authenticated-orcid":false,"given":"Neil","family":"Rajan","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Craig","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Gloucestershire Hospitals NHS Foundation Trust Cheltenham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9929-2693","authenticated-orcid":false,"given":"Zoe Claire","family":"Venables","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia Norwich UK"},{"name":"Department of Dermatology Norfolk and Norwich University Hospital Norwich UK"},{"name":"National Disease Registration Service NHS Digital (NHSD) Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"2023022412434738900_","first-page":"159","volume-title":"WHO Classification of Skin Tumours","author":"Elder DE","year":"2018","edition":"4th edn"},{"key":"2023022412434738900_","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/229255030301100304","article-title":"Eccrine porocarcinoma: a case report and review of the literature","volume":"11","author":"Lloyd","year":"2003","journal-title":"Can J Plast Surg"},{"key":"2023022412434738900_","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1001\/archderm.1963.01590230105015","article-title":"Epidermotropic eccrine carcinoma. a case combining features of eccrine poroma and Paget's dermatosis","volume":"88","author":"Pinkus","year":"1963","journal-title":"Arch Dermatol"},{"key":"2023022412434738900_","first-page":"1227","article-title":"Metastatic eccrine porocarcinoma: a 5.6-year follow-up study of a patient treated with a combined therapeutic protocol","volume":"29","author":"Gonzalez-Lopez","year":"2003","journal-title":"Dermatol Surg"},{"key":"2023022412434738900_","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/00000478-200106000-00002","article-title":"Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases","volume":"25","author":"Robson","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"2023022412434738900_","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ad.2020.01.007","article-title":"Eccrine porocarcinoma: a clinical and histologic description of a series of 11 cases treated at the university hospital complex in Leon, Spain","volume":"112","author":"Olmos Nieva","year":"2021","journal-title":"Actas Dermosifiliogr (Engl Ed)"},{"key":"2023022412434738900_","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1477-7819-9-94","article-title":"Eccrine 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