{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:15:41Z","timestamp":1792134941180,"version":"4.4.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Male genital lichen sclerosus (MGLSc) can lead to significant sexual dysfunction and urological morbidity, and is also a risk factor for premalignant disease (penile intraepithelial neoplasia and penile cancer), particularly squamous cell carcinoma. Although the precise aetiopathogenesis of MGLSc remains controversial, accumulated evidence indicates that it is related to chronic, intermittent, occluded exposure to urine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To perform spatial mapping of MGLSc across the human prepuce and assess how this supports the urinary occlusion hypothesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Preputial samples were collected from 10 patients with clinically diagnosed MGLSc undergoing circumcision. The samples were then divided into a grid pattern and 10 punch biopsies were obtained from each section to determine the extent and distribution of the disease process across each prepuce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 10 patients reported having urinary microincontinence, and all were histologically confirmed as having MGLSc. The most proximal aspect of the prepuce was found to be universally affected by MGLSc in all patients, whereas the most distal part was overwhelmingly shown to be the least affected area. Of the 63 MGLSc-affected regions, 62 were in direct physical contiguity with one another. The histological extent of the disease was not found to be congruent with either the severity of the symptoms reported by the patients or the clinical examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In uncircumcised men with urinary microincontinence, after the prepuce has been replaced post micturition, small amounts of urine can pool between the juxtaposed epithelial surfaces. The proximal aspect of the prepuce is subjected to the maximum amount of occlusion and maximal contact with accumulated urine, whereas the distal prepuce is subjected to the least. Our findings suggest that accentuated contact between urine and susceptible penile epithelium due to occlusion can lead to MGLSc. Furthermore, contiguity data suggest that once established, it is possible that MGLSc advances across tissues by physical contact. This is the first study examining the changes in the preputial landscape in patients with LSc and contributes to our understanding of disease aetiology and progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ced.15127","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T03:03:47Z","timestamp":1644635027000},"page":"1124-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Male genital lichen sclerosus, microincontinence and occlusion: mapping the disease across the prepuce"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-0149","authenticated-orcid":false,"given":"Georgios","family":"Kravvas","sequence":"first","affiliation":[{"name":"Department of Dermatology University College London Hospital University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Muneer","sequence":"additional","affiliation":[{"name":"Department of Urology University College London Hospital University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Watchorn","sequence":"additional","affiliation":[{"name":"Department of Dermatology University College London Hospital University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Castiglione","sequence":"additional","affiliation":[{"name":"Department of Urology University College London Hospital University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiman","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College London Hospital University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Histopathology University College London Hospital University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hadway","sequence":"additional","affiliation":[{"name":"Department of Urology University College London Hospital University College London Hospitals NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussain","family":"Alnajjar","sequence":"additional","affiliation":[{"name":"Department of Urology University College London Hospital University College London Hospitals NHS Foundation Trust London 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(PeIN): clinical and histological features and treatment of 345 patients and a review of the literature","author":"Kravvas","year":"2020","journal-title":"J Dermatolog Treat"},{"key":"2023022412433986800_","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1468-3083.2011.04155.x","article-title":"Clinical parameters in male genital lichen sclerosus: a case series of 329 patients","volume":"26","author":"Edmonds","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023022412433986800_","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/jdv.14488","article-title":"The diagnosis and management of male genital lichen sclerosus: a retrospective review of 301 patients","volume":"32","author":"Kravvas","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023022412433986800_","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/ced.14869","article-title":"Male genital lichen sclerosus associated with urological 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