{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:12:55Z","timestamp":1784304775093,"version":"3.55.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elderly-onset (&amp;gt; 60 years of age) atopic dermatitis and psoriasis have been reported to present special clinical phenotypes; however, the study of elderly-onset generalized pustular psoriasis (GPP) has been limited, mainly due to its rarity. Previous studies have shown that the mean age of GPP onset is around 40 years, and onset at &amp;gt; 60 years of age is extremely rare. We report a case series of seven patients with elderly-onset GPP. The clinical features of the seven patients were assessed, and all seven patient were analysed for presence of the c.115+6T&amp;gt;C mutation in the gene encoding for interleukin-36 receptor antagonist (IL36RN). These patients had an atypical clinical course and a lower frequency of the IL36RN c.115+6T&amp;gt;C mutation. IL36RN mutations may have a significant, dose-dependent effect on the onset age of GPP.<\/jats:p>","DOI":"10.1111\/ced.15227","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T11:24:20Z","timestamp":1650021860000},"page":"1567-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Elderly-onset generalized pustular psoriasis: a case series"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6870-1426","authenticated-orcid":false,"given":"Jen-Ping","family":"Chao","sequence":"first","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-1474","authenticated-orcid":false,"given":"Tsen-Fang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital Taipei Taiwan"},{"name":"Department of Dermatology National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"2023041114210144000_","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1111\/jdv.14386","article-title":"European consensus statement on phenotypes of pustular psoriasis","volume":"31","author":"Navarini","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023041114210144000_","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/1346-8138.15958","article-title":"Clinical analysis of generalized pustular psoriasis in Chinese patients: a retrospective study of 110 patients","volume":"48","author":"Zheng","year":"2021","journal-title":"J Dermatol"},{"key":"2023041114210144000_","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/ijd.12070","article-title":"Clinical profile, morbidity, and outcome of adult-onset generalized pustular psoriasis: analysis of 102 cases seen in a tertiary hospital in Johor","volume":"53","author":"Choon","year":"2014","journal-title":"Malaysia. 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