{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:52:46Z","timestamp":1788828766408,"version":"build-2803163510"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"vor","delay-in-days":98,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"UK Dermatology Clinical Trials Network","award":["UK DCTN (UK DCTN 2014 Themed Call Research Award D"],"award-info":[{"award-number":["UK DCTN (UK DCTN 2014 Themed Call Research Award D"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Compression therapy is considered beneficial for postsurgical lower leg wound healing by secondary intention; however, there is a lack of supportive evidence. To plan a randomized controlled trial (RCT), suitable data are needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To determine the feasibility of recruitment and estimate recruitment rate; to understand the standard postoperative wound management pathway; to determine uptake of optional additional clinic visits for healing confirmation; and to explore patient acceptability of compression bandaging and plan a future RCT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Participant recruitment was performed from secondary care dermatology clinics, during a period of 22 months. Inclusion criteria were age \u2265 18 years, planned excision of keratinocyte cancer on the lower leg with healing by secondary intention and an ankle\u2013brachial pressure index of \u2265 0.8. Exclusion criteria were planned primary closure\/graft or flap; inability to receive, comply with or tolerate high compression; planned compression; or suspected melanoma. Patients were followed up weekly (maximum 6 months) in secondary care clinics and\/or by telephone. Information was collected on healthcare resource use, unplanned compression, wound healing and an optional clinic visit to confirm healing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This study recruited 58 patients from 9 secondary care dermatology clinics over 22 months. Mean recruitment\/centre\/month was 0.8 (range 0.1\u20132.3). Four centres had dedicated Research Nurse support. The analysis population (n = 53) had weekly follow-up assessments. Standard care clinical contacts were: general practitioner (7 visits; 1.2%), community nurse (169; 28.5%), practice nurse visits (189; 31.8%) and dermatology clinic visits (138; 23.2%). Participants whose wounds healed (34 of 45; 75.6%) attended an optional clinic visit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Data were obtained to inform a future RCT. Recruitment rates were found to be higher in centres with dedicated research support. People would be willing to take part in a trial and attend a confirmation of healing visit.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/ced.15283","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T05:09:51Z","timestamp":1654319391000},"page":"1839-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Healing of ExcisionAl wounds on Lower legs by Secondary intention (HEALS) cohort study. Part 2: feasibility data from a multicentre prospective observational cohort study to inform a future randomized controlled trial"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3326-7900","authenticated-orcid":false,"given":"Rachael","family":"Gilberts","sequence":"first","affiliation":[{"name":"Leeds Institute of Clinical Trials Research University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2848-9149","authenticated-orcid":false,"given":"Elizabeth","family":"McGinnis","sequence":"additional","affiliation":[{"name":"Leeds Institute of Clinical Trials Research University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myka","family":"Ransom","sequence":"additional","affiliation":[{"name":"Leeds Institute of Clinical Trials Research University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma V.","family":"Pynn","sequence":"additional","affiliation":[{"name":"Aneurin Bevan University Health Board Royal Gwent Hospital Newport UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Walker","sequence":"additional","affiliation":[{"name":"Harrogate District Hospital Harrogate and District NHS Foundation Trust Harrogate UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Brown","sequence":"additional","affiliation":[{"name":"Leeds Institute of Clinical Trials Research University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Trehan","sequence":"additional","affiliation":[{"name":"Broadgreen Hospital Liverpool University Hospitals NHS Foundation Trust Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prativa","family":"Jayasekera","sequence":"additional","affiliation":[{"name":"Royal Victoria Infirmary The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2533-1899","authenticated-orcid":false,"given":"David","family":"Veitch","sequence":"additional","affiliation":[{"name":"Leicester Royal Infirmary University Hospitals of Leicester NHS Trust Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walayat","family":"Hussain","sequence":"additional","affiliation":[{"name":"Chapel Allerton Hospital Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemma","family":"Collins","sequence":"additional","affiliation":[{"name":"University Hospital of Wales Cardiff and Vale University Health Board Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-7132","authenticated-orcid":false,"given":"Rachel Angharad","family":"Abbott","sequence":"additional","affiliation":[{"name":"University Hospital of Wales Cardiff and Vale University Health Board Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun Sen","family":"Chen","sequence":"additional","affiliation":[{"name":"West Suffolk Hospital West Suffolk NHS Foundation Trust Bury St Edmunds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-7698","authenticated-orcid":false,"given":"Jane","family":"Nixon","sequence":"additional","affiliation":[{"name":"Leeds Institute of Clinical Trials Research University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"2023010808125723600_ced15283-bib-0001","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/ced.15103","article-title":"Does the use of compression bandaging as an adjunct improve outcomes 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