{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:07:42Z","timestamp":1785686862051,"version":"3.56.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aquagenic wrinkling of the palms (AWP) is a rare dermatological disease characterized by development of rapid and excessive wrinkling and oedema of the palms and transient whitish or yellowish papules without erythema on the palmar surfaces after immersion in water. This phenomenon can be accompanied by pain and\/or pruritus. The most common treatment of AWP involves aluminium-based topicals. This article discusses the associations, pathological mechanisms and treatment options of AWP.<\/jats:p>","DOI":"10.1111\/ced.15323","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T08:31:21Z","timestamp":1657182681000},"page":"1910-1915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Aquagenic wrinkling of the palms: review of the literature"],"prefix":"10.1093","volume":"47","author":[{"given":"Karen","family":"Yang","sequence":"first","affiliation":[{"name":"School of Medicine University of California Riverside CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cici","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Loma Linda University Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janiene","family":"Luke","sequence":"additional","affiliation":[{"name":"Department of Dermatology Loma Linda University Loma Linda CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"2023010808131391800_ced15323-bib-0001","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/2229-5178.126025","article-title":"Aquagenic keratoderma. Two new case reports and a new hypothesis","volume":"5","author":"Wollina","year":"2014","journal-title":"Indian Dermatol Online J"},{"key":"2023010808131391800_ced15323-bib-0002","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5070\/D35D57W5ZZ","article-title":"Aquagenic wrinkling of the palms: a case report and literature review","volume":"16","author":"Syed","year":"2010","journal-title":"Dermatol Online J"},{"key":"2023010808131391800_ced15323-bib-0003","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000355183","article-title":"Aquagenic wrinkling of the palms and cystic fibrosis: an Italian study with controls and genotype-phenotype correlations","volume":"228","author":"Chinazzo","year":"2014","journal-title":"Dermatology"},{"key":"2023010808131391800_ced15323-bib-0004","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5021\/ad.2020.32.2.151","article-title":"Two cases of aquagenic wrinkling of the palms in Korean healthy women: easily overlooked disease","volume":"32","author":"Choi","year":"2020","journal-title":"Ann Dermatol"},{"key":"2023010808131391800_ced15323-bib-0005","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1365-2133.2010.09914.x","article-title":"Aquagenic wrinkling of the palms in cystic fibrosis and the cystic fibrosis carrier state: a case-control study: AWP in CF and the CF carrier state","volume":"163","author":"Gild","year":"2010","journal-title":"Br J Dermatol"},{"key":"2023010808131391800_ced15323-bib-0006","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1525-1470.2011.01609.x","article-title":"Aquagenic wrinkling of the palms and the potential role for genetic testing: aquagenic wrinkling of the palms","volume":"29","author":"Park","year":"2012","journal-title":"Pediatr Dermatol"},{"key":"2023010808131391800_ced15323-bib-0007","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1525-1470.2006.00168.x","article-title":"Transient aquagenic palmar hyperwrinkling: the first instance reported in a young boy","volume":"23","author":"Neri","year":"2006","journal-title":"Pediatr Dermatol"},{"key":"2023010808131391800_ced15323-bib-0008","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2133.2008.08633.x","article-title":"Aquagenic syringeal acrokeratoderma: unusual prominence on the dorsal aspect of fingers?","volume":"159","author":"Yoon","year":"2008","journal-title":"Br J Dermatol"},{"key":"2023010808131391800_ced15323-bib-0009","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/j.1365-4632.2010.04803.x","article-title":"Aquagenic acrokeratoderma: case report with no involvement of the palms: correspondence","volume":"51","author":"Xia","year":"2012","journal-title":"Int J Dermatol"},{"key":"2023010808131391800_ced15323-bib-0010","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4103\/ijmr.IJMR_1139_16","article-title":"Aquagenic wrinkling syndrome involving forehead: an unusual presentation","volume":"147","author":"Bajaj","year":"2018","journal-title":"Indian J Med Res"},{"key":"2023010808131391800_ced15323-bib-0011","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1001\/archderm.142.12.1661","article-title":"Unilateral aquagenic wrinkling of the palms associated with aspirin intake","volume":"142","author":"Khuu","year":"2006","journal-title":"Arch Dermatol"},{"key":"2023010808131391800_ced15323-bib-0012","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1365-4632.2009.04304.x","article-title":"Aquagenic acrokeratoderma: aquagenic acrokeratoderma","volume":"49","author":"Luo","year":"2010","journal-title":"Int J Dermatol"},{"key":"2023010808131391800_ced15323-bib-0013","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1365-2133.2012.11003.x","article-title":"Aquagenic (pseudo) keratoderma: a clinical series with new pathological insights: aquagenic (pseudo) keratoderma","volume":"167","author":"Rongioletti","year":"2012","journal-title":"Br J Dermatol"},{"key":"2023010808131391800_ced15323-bib-0014","first-page":"813","article-title":"Rofecoxib-induced aquagenic edema with puckering of the palms of the hands: the first case","volume":"130","author":"Schmutz","year":"2003","journal-title":"Ann Dermatol Venereol"},{"key":"2023010808131391800_ced15323-bib-0015","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2133.2010.09764.x","article-title":"Frequency of aquagenic palmoplantar keratoderma in cystic fibrosis: a new sign of cystic fibrosis?","volume":"163","author":"Gar\u00e7on-Michel","year":"2010","journal-title":"Br J Dermatol"},{"key":"2023010808131391800_ced15323-bib-0016","article-title":"Aquagenic wrinkling of the palm: a rare diagnostic clue of cystic fibrosis and the response to CFTR-modulating therapy","volume":"13","author":"Torres-Laboy","year":"2021","journal-title":"Cureus"},{"key":"2023010808131391800_ced15323-bib-0017","first-page":"135","article-title":"The relevance of sweat testing for the diagnosis of cystic fibrosis in the genomic era","volume":"26","author":"Mishra","year":"2005","journal-title":"Clin Biochem Rev"},{"issue":"Suppl","key":"2023010808131391800_ced15323-bib-0018","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.jaad.2008.04.023","article-title":"Aberrant aquaporin 5 expression in the sweat gland in aquagenic wrinkling of the palms","volume":"59","author":"Kabashima","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"2023010808131391800_ced15323-bib-0019","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1111\/jdv.17312","article-title":"Aquagenic wrinkling of the palms after brief immersion to water test as a screening tool for cystic fibrosis diagnosis","volume":"35","author":"Alexopoulos","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808131391800_ced15323-bib-0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.47878\/hi.1983.v8.35587","article-title":"Lack of wrinkle formation in the fingertips of patients with Hansen's disease. Confirmation of previous observations","volume":"8","author":"Sheskin","year":"1983","journal-title":"Hansenol Int"},{"key":"2023010808131391800_ced15323-bib-0021","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/mus.10323","article-title":"Water-immersion wrinkling is due to vasoconstriction","volume":"27","author":"Wilder-Smith","year":"2003","journal-title":"Muscle Nerve"},{"key":"2023010808131391800_ced15323-bib-0022","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10286-004-0172-4","article-title":"Water immersion wrinkling","volume":"14","author":"Wilder-Smith","year":"2004","journal-title":"Clin Auton Res"},{"key":"2023010808131391800_ced15323-bib-0023","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1046\/j.1525-1470.2002.00103.x","article-title":"Rofecoxib-induced instant aquagenic wrinkling of the palms","volume":"19","author":"Carder","year":"2002","journal-title":"Pediatr Dermatol"},{"key":"2023010808131391800_ced15323-bib-0024","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1067\/mjd.2001.113479","article-title":"Aquagenic palmoplantar keratoderma","volume":"44","author":"Yan","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"2023010808131391800_ced15323-bib-0025","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1067\/mjd.2001.114586","article-title":"Aquagenic syringeal acrokeratoderma: report of two teenage cases","volume":"45","author":"MacCormack","year":"2001","journal-title":"J Am Acad Dermatol"},{"key":"2023010808131391800_ced15323-bib-0026","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5070\/D35158Q15Q","article-title":"Hereditary papulotranslucent acrokeratoderma","volume":"14","author":"Rizzo","year":"2008","journal-title":"Dermatol Online J"},{"key":"2023010808131391800_ced15323-bib-0027","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1365-4632.2004.02275.x","article-title":"Familial aquagenic acrokeratoderma: case reports and review of the literature","volume":"44","author":"Saray","year":"2005","journal-title":"Int J Dermatol"},{"key":"2023010808131391800_ced15323-bib-0028","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1525-1470.2007.00525.x","article-title":"Unilateral transient reactive papulotranslucent acrokeratoderma in a child","volume":"24","author":"Erkek","year":"2007","journal-title":"Pediatr Dermatol"},{"key":"2023010808131391800_ced15323-bib-0029","first-page":"602","article-title":"Aquagenic cutaneous disorders","volume":"15","author":"Wang","year":"2017","journal-title":"J Dtsch Dermatol Ges"},{"key":"2023010808131391800_ced15323-bib-0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3315\/jdcr.2010.1045","article-title":"Unilateral aquagenic keratoderma treated with botulinum toxin A","volume":"4","author":"Houle","year":"2010","journal-title":"J Dermatol Case Rep"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ced.15323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ced.15323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/47\/11\/1910\/48530628\/ced1910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/47\/11\/1910\/48530628\/ced1910.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T17:43:14Z","timestamp":1727545394000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/47\/11\/1910\/6966107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,1]]},"published-print":{"date-parts":[[2022,11,1]]}},"URL":"https:\/\/doi.org\/10.1111\/ced.15323","relation":{},"ISSN":["1365-2230","0307-6938"],"issn-type":[{"value":"1365-2230","type":"electronic"},{"value":"0307-6938","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,11,1]]},"published":{"date-parts":[[2022,11,1]]},"assertion":[{"value":"2022-07-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}