{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T12:04:43Z","timestamp":1750680283518,"version":"3.37.3"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Individuals with a prior diagnosis of chronic lymphocytic leukaemia (CLL) have a higher risk of developing melanoma and exhibit poorer outcomes than patients without CLL. However, there are limited data reporting the clinicopathological features of melanoma diagnosed in patients with CLL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To review clinicopathological characteristics of patients with coexisting diagnoses of melanoma and CLL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective review was undertaken for patients with coexisting diagnoses of melanoma and CLL between 2005 and 2015 in 11 centres in the UK and Ireland.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 46 cutaneous melanomas identified in 45 patients were included. In 28 (62.2%) patients, melanoma was diagnosed after an existing diagnosis of CLL. In this group, mean Breslow thickness was 2.7 mm (range 0.2\u201325 mm). Ten patients (35.7%) developed locoregional recurrence and 8 (28.6%) developed distant metastases. Melanoma-specific mortality was 5 of 28 (17.9%) and all-cause mortality was 13 of 28 (46.4%). In 17 patients, melanoma was diagnosed before CLL. In this group, mean BT was 2.9 mm (range 0.4\u201314 mm); five patients (29.4%) developed locoregional recurrence and three (17.6%) developed distant metastases. Melanoma-specific mortality was 1 of 17 (5.8%) and all-cause mortality was 5 of 17 (29.4%) in this group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>To our knowledge, this is the first and largest cohort study to report clinicopathological data of coexisting melanoma and CLL in the UK and Ireland. Although the thickness of primary melanoma was not different before or after a CLL diagnosis, melanoma recurrence and melanoma-specific mortality appear to be more common in patients with a prior diagnosis of CLL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1111\/ced.15324","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T08:31:33Z","timestamp":1657269093000},"page":"1976-1981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological characteristics of individuals with coexisting melanoma and chronic lymphocytic leukaemia: a multicentre cohort study"],"prefix":"10.1093","volume":"47","author":[{"given":"Rachel Mary","family":"Fisher","sequence":"first","affiliation":[{"name":"Department of Dermatology Oxford University Hospitals NHS Foundation Trust Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-181X","authenticated-orcid":false,"given":"Antonio","family":"Ji-Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oxford University Hospitals NHS Foundation Trust Oxford UK"},{"name":"Department of Dermatology University of California, Davis Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Abbott","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cardiff and Vale University Health Board Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Dermatology King's College Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair","family":"Brown","sequence":"additional","affiliation":[{"name":"Charles Centre Department of Dermatology Royal Devon and Exeter NHS Foundation Trust Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Foley","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Vincent's University Hospital Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"Glen","sequence":"additional","affiliation":[{"name":"Department of Dermatology NHS Lanarkshire Lanarkshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dermatology NHS Lanarkshire Lanarkshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeeshaan","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferina","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Free London NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ninewells Hospital and Medical School Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-1438","authenticated-orcid":false,"given":"Andre B. 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