{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:48:58Z","timestamp":1783406938700,"version":"3.54.6"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Minoxidil solution is used for the treatment of androgenetic alopecia (AGA). Minoxidil 5% solution has been shown to have superior efficacy to minoxidil 2% solution, it is unknown whether concentrations of minoxidil &amp;gt; 5% provide additional clinical benefit. We performed a review of the literature to examine the evidence on the efficacy and safety of higher concentrations of minoxidil in AGA. A search of the PubMed database was performed using the keywords \u2018minoxidil\u2019, \u2018androgenic alopecia\u2019 and \u2018pattern hair loss\u2019. Relevant articles, including clinical trials, other clinical studies, case series and case reports published in English were considered for review. In addition, relevant references from the bibliography section of the retrieved articles were also reviewed.<\/jats:p>","DOI":"10.1111\/ced.15338","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T20:44:15Z","timestamp":1658868255000},"page":"1951-1955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Does topical minoxidil at concentrations higher than 5% provide additional clinical benefit?"],"prefix":"10.1093","volume":"47","author":[{"given":"Shreya","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Dermatology Seth G.S. Medical College and K.E.M. Hospital Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Dr DY Patil Medical College Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4768-0598","authenticated-orcid":false,"given":"Nika","family":"Kianfar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-3589","authenticated-orcid":false,"given":"Anna","family":"Wa\u015bkiel-Burnat","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8308-1023","authenticated-orcid":false,"given":"Lidia","family":"Rudnicka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Melbourne Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-1179","authenticated-orcid":false,"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"2023010808131693200_ced15338-bib-0001","doi-asserted-by":"crossref","DOI":"10.1111\/dth.13195","article-title":"Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil treatment in Brazilian female pattern hair loss patients","volume":"33","author":"Ramos","year":"2020","journal-title":"Dermatol Ther"},{"key":"2023010808131693200_ced15338-bib-0002","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1111\/jdv.16765","article-title":"Minoxidil sulfotransferase enzyme (SULT1A1) genetic variants predicts response to oral minoxidil treatment for female pattern hair loss","volume":"35","author":"Ramos","year":"2021","journal-title":"J Eur Acad Dermatol 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minoxidil-loaded nanotechnology strategies for alopecia","volume":"7","author":"Santos","year":"2020","journal-title":"Cosmetics"},{"key":"2023010808131693200_ced15338-bib-0007","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.668754","article-title":"Minoxidil-coated lysozyme-shelled microbubbes combined with ultrasound for the enhancement of hair follicle growth: efficacy in vitro and in vivo","volume":"12","author":"Liao","year":"2021","journal-title":"Front Pharmacol"},{"key":"2023010808131693200_ced15338-bib-0008","first-page":"185","article-title":"Topical minoxidil: systematic review and meta-analysis of its efficacy in androgenetic alopecia","volume":"13","author":"Gupta","year":"2015","journal-title":"Skinmed"},{"key":"2023010808131693200_ced15338-bib-0009","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1067\/mjd.2002.124088","article-title":"A randomized clinical trial of 5% topical minoxidil versus 2% topical minoxidil and placebo in the treatment of androgenetic alopecia in men","volume":"47","author":"Olsen","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"2023010808131693200_ced15338-bib-0010","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1346-8138.2009.00673.x","article-title":"Randomized clinical trial comparing 5% and 1% topical minoxidil for the treatment of androgenetic alopecia in Japanese men","volume":"36","author":"Tsuboi","year":"2009","journal-title":"J Dermatol"},{"key":"2023010808131693200_ced15338-bib-0011","first-page":"155","article-title":"The efficacy of topical minoxidil for non-scarring alopecia: a systematic review","volume":"18","author":"Sung","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"2023010808131693200_ced15338-bib-0012","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/09546630701383727","article-title":"Is topical minoxidil solution effective on androgenetic alopecia in routine daily 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