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In severe cases, ectropion of the eyelid may occur, and erythroderma may further develop. Recently, it has been reported that secukinumab, a monoclonal anti-interleukin-17A antibody, has certain efficacy in the treatment of PRP. Herein, we report a 3-year-old Chinese boy with severe Type III (classic juvenile) PRP who was successfully treated with secukinumab alone.<\/jats:p>","DOI":"10.1111\/ced.15353","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T21:03:05Z","timestamp":1659128585000},"page":"2043-2045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of severe pityriasis rubra pilaris with secukinumab in a 3-year-old boy"],"prefix":"10.1093","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0270-5667","authenticated-orcid":false,"given":"Yong-Hui","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-Dan","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Mei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Qiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Guangdong Medical University Zhanjiang Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"2023010808133062300_ced15353-bib-0001","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/11530070-000000000-00000","article-title":"Pityriasis rubra pilaris","volume":"11","author":"Klein","year":"2010","journal-title":"Am J Clin Dermatol"},{"key":"2023010808133062300_ced15353-bib-0002","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1001\/jamadermatol.2016.5384","article-title":"Interleukin 23\u2013helper T cell 17 axis as a treatment target for pityriasis rubra pilaris","volume":"153","author":"Feldmeyer","year":"2017","journal-title":"JAMA Dermatol"},{"key":"2023010808133062300_ced15353-bib-0003","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11926-007-0075-1","article-title":"Pathophysiology of psoriasis: recent advances on IL-23 and Th17 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