{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T10:29:07Z","timestamp":1774434547826,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The prevention and early detection of venous thromboembolism (VTE), including pulmonary embolism (PE), is essential in daily medical practice. We previously reported the risk of VTE in patients with autoimmune blistering disease (AIBD). We have also experienced multiple cases of pemphigus or pemphigoid that developed severe complications related to abnormal blood coagulation other than VTE. This study summarizes and discusses those cases. Nine patients with AIBD developed thromboembolism and\/or bleeding; these included (some patients overlapped) six patients with VTE, including five patients with PE; three patients with severe bleeding; one patient with sudden critical limb ischaemia resulting in thigh amputation; and one patient with cerebral infarction. Although five patients developed PE, only one had apparent respiratory symptoms with PE, and a second developed severe bleeding during the treatment for PE. Clinicians should be aware of the systemic complications related to abnormal blood coagulation when treating patients with AIBD.<\/jats:p>","DOI":"10.1111\/ced.15375","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T07:34:25Z","timestamp":1660376065000},"page":"2255-2260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thromboembolism and bleeding in patients with autoimmune blistering disease"],"prefix":"10.1093","volume":"47","author":[{"given":"Yuriko","family":"Sho","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Oita University Yufu-shi Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Oita University Yufu-shi Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruna","family":"Matsuda-Hirose","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Oita University Yufu-shi Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Yamate","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Oita University Yufu-shi Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Oita University Yufu-shi Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2023010808134621200_ced15375-bib-0001","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1093\/eurheartj\/ehu283","article-title":"Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism","volume":"35","author":"Konstantinides","year":"2014","journal-title":"Eur Heart J"},{"key":"2023010808134621200_ced15375-bib-0002","first-page":"2269","article-title":"[Management of venous thromboembolism in dermatological practice] (in Japanese)","volume":"128","author":"Sakai","year":"2018","journal-title":"Jpn J Dermatol"},{"key":"2023010808134621200_ced15375-bib-0003","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaad.2017.01.059","article-title":"Venous thromboembolism in patients with pemphigus: a cohort study","volume":"77","author":"Leshem","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"2023010808134621200_ced15375-bib-0004","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1160\/TH15-04-0309","article-title":"Increased risk of venous thromboembolism in patients with bullous pemphigoid. The INVENTEP (INcidence of VENous ThromboEmbolism in bullous Pemphigoid) study","volume":"115","author":"Cugno","year":"2016","journal-title":"Thromb Haemost"},{"key":"2023010808134621200_ced15375-bib-0005","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.thromres.2019.05.019","article-title":"It's time for head-to-head trials with direct oral anticoagulants","volume":"180","author":"Tritschler","year":"2019","journal-title":"Thromb Res"},{"key":"2023010808134621200_ced15375-bib-0006","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12328-014-0476-4","article-title":"A case of bleeding duodenal ulcer with pemphigus vulgaris during steroid therapy","volume":"7","author":"Niho","year":"2014","journal-title":"Clin J Gastroenterol"},{"key":"2023010808134621200_ced15375-bib-0007","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1684\/ejd.2018.3284","article-title":"A case of acquired haemophilia A in a patient with bullous pemphigoid and review of the Japanese literature","volume":"28","author":"Chijiwa","year":"2018","journal-title":"Eur J Dermatol"},{"key":"2023010808134621200_ced15375-bib-0008","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12185-020-03002-9","article-title":"Bullous pemphigoid is a common associated disorder with acquired haemophilia A","volume":"113","author":"Abdul-Halim","year":"2021","journal-title":"Int J Hematol"},{"key":"2023010808134621200_ced15375-bib-0009","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/jdv.15444","article-title":"Neurological disorders are associated with bullous pemphigoid","volume":"33","author":"Papakonstantinou","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023010808134621200_ced15375-bib-0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2249.2009.03989.x","article-title":"Coagulation activation in autoimmune bullous diseases","volume":"158","author":"Marzano","year":"2009","journal-title":"Clin Exp Immunol"}],"container-title":["Clinical and Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ced.15375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ced.15375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/47\/12\/2255\/48531355\/ced2255.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ced\/article-pdf\/47\/12\/2255\/48531355\/ced2255.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T14:58:56Z","timestamp":1676386736000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ced\/article\/47\/12\/2255\/6966233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,1]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,1]]},"published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1111\/ced.15375","relation":{},"ISSN":["1365-2230","0307-6938"],"issn-type":[{"value":"1365-2230","type":"electronic"},{"value":"0307-6938","type":"print"}],"subject":[],"published-other":{"date-parts":[[2022,12,1]]},"published":{"date-parts":[[2022,12,1]]},"assertion":[{"value":"2022-08-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}